Next Article in Journal
Determination of Specific Heat Capacity on Composite Shape-Stabilized Phase Change Materials and Asphalt Mixtures by Heat Exchange System
Next Article in Special Issue
Chemical Characterization and in Vitro Antibacterial Activity of Myrcianthes hallii (O. Berg) McVaugh (Myrtaceae), a Traditional Plant Growing in Ecuador
Previous Article in Journal
Streamlined Membrane Proteome Preparation for Shotgun Proteomics Analysis with Triton X-100 Cloud Point Extraction and Nanodiamond Solid Phase Extraction
Previous Article in Special Issue
Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials
Open AccessFeature PaperReview

Innate Immune Response in Implant-Associated Infections: Neutrophils against Biofilms

1
Center for Orthopaedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, Heidelberg 69118, Germany
2
Institute for Immunology, Heidelberg University, Im Neuenheimer Feld 305, Heidelberg 69120, Germany
3
Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna 40136, Italy
4
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna 40126, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Jaroslaw W. Drelich
Materials 2016, 9(5), 387; https://doi.org/10.3390/ma9050387
Received: 20 February 2016 / Revised: 28 April 2016 / Accepted: 6 May 2016 / Published: 18 May 2016
(This article belongs to the Special Issue Anti-Infective Materials in Medicine and Technology)
Biofilm has been recognized as a well-protected form of living for bacteria, contributing to bacterial pathogenicity, particularly for opportunistic species. Biofilm-associated infections are marked by their persistence. Extensive research has been devoted to the formation and composition of biofilms. The immune response against biofilms remains rather unexplored, but there is the notion that bacteria within a biofilm are protected from host defences. Here we glance at the mechanisms by which neutrophils recognize and face biofilms in implant infections and discuss the implications of this interplay, as well as speculate on its significance. View Full-Text
Keywords: implant infections; biofilm; innate immune response; neutrophils; GroEL; Staphylococcus; orthopedics implant infections; biofilm; innate immune response; neutrophils; GroEL; Staphylococcus; orthopedics
Show Figures

Figure 1

MDPI and ACS Style

Dapunt, U.; Hänsch, G.M.; Arciola, C.R. Innate Immune Response in Implant-Associated Infections: Neutrophils against Biofilms. Materials 2016, 9, 387.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop