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Innate Immune Response in Implant-Associated Infections: Neutrophils against Biofilms

Center for Orthopaedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, Heidelberg 69118, Germany
Institute for Immunology, Heidelberg University, Im Neuenheimer Feld 305, Heidelberg 69120, Germany
Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna 40136, Italy
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna 40126, Italy
Author to whom correspondence should be addressed.
Academic Editor: Jaroslaw W. Drelich
Materials 2016, 9(5), 387;
Received: 20 February 2016 / Revised: 28 April 2016 / Accepted: 6 May 2016 / Published: 18 May 2016
(This article belongs to the Special Issue Anti-Infective Materials in Medicine and Technology)
PDF [1715 KB, uploaded 18 May 2016]


Biofilm has been recognized as a well-protected form of living for bacteria, contributing to bacterial pathogenicity, particularly for opportunistic species. Biofilm-associated infections are marked by their persistence. Extensive research has been devoted to the formation and composition of biofilms. The immune response against biofilms remains rather unexplored, but there is the notion that bacteria within a biofilm are protected from host defences. Here we glance at the mechanisms by which neutrophils recognize and face biofilms in implant infections and discuss the implications of this interplay, as well as speculate on its significance. View Full-Text
Keywords: implant infections; biofilm; innate immune response; neutrophils; GroEL; Staphylococcus; orthopedics implant infections; biofilm; innate immune response; neutrophils; GroEL; Staphylococcus; orthopedics

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Dapunt, U.; Hänsch, G.M.; Arciola, C.R. Innate Immune Response in Implant-Associated Infections: Neutrophils against Biofilms. Materials 2016, 9, 387.

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