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Open AccessArticle

Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues

School of Pharmaceutical Science, Shandong University, 44 Wenhua Xi Road, Ji'nan 250012, Shandong, China
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Academic Editor: Loo Say Chye Joachim
Materials 2015, 8(2), 379-391; https://doi.org/10.3390/ma8020379
Received: 17 November 2014 / Accepted: 13 January 2015 / Published: 23 January 2015
(This article belongs to the Special Issue Materials for Drug Delivery)
A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined nano-micelles in aqueous solution because of their obvious amphiphilic property and low critical micelle concentration. The spherical morphology and particle size of the prepared nano-micelles were characterized by transmission electron microscopy and dynamic light scattering, respectively. Moreover, after the introduction of pH sensitive hydrazone bond, P123-DTX micelle showed a pH dependent drug release behavior. At pH 5.0 (in 48 h), the cumulative release amount of DTX were ~84.9%, which is about six times higher than that at pH 7.4. The prepared novel p123-DTX conjugates may offer a great benefit for drug delivery and controlling the drug release. View Full-Text
Keywords: docetaxel; conjugates; nano-micelles; stability; pH controlled release docetaxel; conjugates; nano-micelles; stability; pH controlled release
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MDPI and ACS Style

Liang, Y.; Su, Z.; Yao, Y.; Zhang, N. Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues. Materials 2015, 8, 379-391.

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