Next Article in Journal
A Miniaturized Antenna with Negative Index Metamaterial Based on Modified SRR and CLS Unit Cell for UWB Microwave Imaging Applications
Next Article in Special Issue
Exploring the Preparation of Albendazole-Loaded Chitosan-Tripolyphosphate Nanoparticles
Previous Article in Journal
Sorption Isotherm of Southern Yellow Pine—High Density Polyethylene Composites
Previous Article in Special Issue
Cholesterol-Enhanced Polylactide-Based Stereocomplex Micelle for Effective Delivery of Doxorubicin
Article Menu

Export Article

Open AccessArticle
Materials 2015, 8(2), 379-391;

Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues

School of Pharmaceutical Science, Shandong University, 44 Wenhua Xi Road, Ji'nan 250012, Shandong, China
Author to whom correspondence should be addressed.
Academic Editor: Loo Say Chye Joachim
Received: 17 November 2014 / Accepted: 13 January 2015 / Published: 23 January 2015
(This article belongs to the Special Issue Materials for Drug Delivery)
Full-Text   |   PDF [928 KB, uploaded 23 January 2015]   |  


A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined nano-micelles in aqueous solution because of their obvious amphiphilic property and low critical micelle concentration. The spherical morphology and particle size of the prepared nano-micelles were characterized by transmission electron microscopy and dynamic light scattering, respectively. Moreover, after the introduction of pH sensitive hydrazone bond, P123-DTX micelle showed a pH dependent drug release behavior. At pH 5.0 (in 48 h), the cumulative release amount of DTX were ~84.9%, which is about six times higher than that at pH 7.4. The prepared novel p123-DTX conjugates may offer a great benefit for drug delivery and controlling the drug release. View Full-Text
Keywords: docetaxel; conjugates; nano-micelles; stability; pH controlled release docetaxel; conjugates; nano-micelles; stability; pH controlled release

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Liang, Y.; Su, Z.; Yao, Y.; Zhang, N. Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues. Materials 2015, 8, 379-391.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top