Next Article in Journal
TiO2-Mediated Photocatalytic Mineralization of a Non-Ionic Detergent: Comparison and Combination with Other Advanced Oxidation Procedures
Next Article in Special Issue
Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues
Previous Article in Journal
Nanoindentation and XPS Studies of Titanium TNZ Alloy after Electrochemical Polishing in a Magnetic Field
Previous Article in Special Issue
Sustained Release of Hydrophilic l-ascorbic acid 2-phosphate Magnesium from Electrospun Polycaprolactone Scaffold—A Study across Blend, Coaxial, and Emulsion Electrospinning Techniques
Article Menu

Export Article

Open AccessArticle
Materials 2015, 8(1), 216-230;

Cholesterol-Enhanced Polylactide-Based Stereocomplex Micelle for Effective Delivery of Doxorubicin

Department of Urology, the First Hospital of Jilin University, Changchun 130021, China
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
Authors to whom correspondence should be addressed.
Academic Editor: Loo Say Chye Joachim
Received: 13 December 2014 / Accepted: 7 January 2015 / Published: 12 January 2015
(This article belongs to the Special Issue Materials for Drug Delivery)
Full-Text   |   PDF [1550 KB, uploaded 12 January 2015]   |  


Nanoscale micelles as an effective drug delivery system have attracted increasing interest in malignancy therapy. The present study reported the construction of the cholesterol-enhanced doxorubicin (DOX)-loaded poly(D-lactide)-based micelle (CDM/DOX), poly(L-lactide)-based micelle (CLM/DOX), and stereocomplex micelle (CSCM/DOX) from the equimolar enantiomeric 4-armed poly(ethylene glycol)–polylactide copolymers in aqueous condition. Compared with CDM/DOX and CLM/DOX, CSCM/DOX showed the smallest hydrodynamic size of 96 ± 4.8 nm and the slowest DOX release. The DOX-loaded micelles exhibited a weaker DOX fluorescence inside mouse renal carcinoma cells (i.e., RenCa cells) compared to free DOX·HCl, probably because of a slower DOX release. More importantly, all the DOX-loaded micelles, especially CSCM/DOX, exhibited the excellent antiproliferative efficacy that was equal to or even better than free DOX·HCl toward RenCa cells attributed to their successful internalization. Furthermore, all of the DOX-loaded micelles exhibited the satisfactory hemocompatibility compared to free DOX·HCl, indicating the great potential for systemic chemotherapy through intravenous injection. View Full-Text
Keywords: cholesterol; controlled delivery; doxorubicin; malignancy therapeutics; polylactide; stereocomplex micelle cholesterol; controlled delivery; doxorubicin; malignancy therapeutics; polylactide; stereocomplex micelle

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Wang, J.; Xu, W.; Ding, J.; Lu, S.; Wang, X.; Wang, C.; Chen, X. Cholesterol-Enhanced Polylactide-Based Stereocomplex Micelle for Effective Delivery of Doxorubicin. Materials 2015, 8, 216-230.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top