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10.3390/ma19102108
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

An Alginate Hydrogel–Lipid Nanodispersion Bio-Mask: A Preliminary Study of Skin Hydration, Barrier Function, and Regenerative Potential

by
Małgorzata Miastkowska
1,*,
Agnieszka Kulawik-Pióro
1,
Anna Sienkiewicz
1,
Anna Łętocha
1,
Katarzyna Malarz
2,
Anna Mrozek-Wilczkiewicz
2,3 and
Katarzyna Bialik-Wąs
1
1
Cracow University of Technology, Faculty of Chemical Engineering and Technology, Warszawska 24, 31-155 Cracow, Poland
2
August Chelkowski Institute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzow, Poland
3
Department of Systems Biology and Engineering, Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, Akademicka 16, 44-100 Gliwice, Poland
*
Author to whom correspondence should be addressed.
Materials 2026, 19(10), 2108; https://doi.org/10.3390/ma19102108
Submission received: 2 April 2026 / Revised: 3 May 2026 / Accepted: 14 May 2026 / Published: 17 May 2026
(This article belongs to the Special Issue Functional Hydrogel for Biomedical Applications: Progress, Challenges, and Opportunities)
Versions Notes

Abstract

Laser therapy is commonly associated with transient skin reactions such as erythema and edema, creating a need for effective post-procedural skincare strategies. In this study, we developed and characterized a novel bio-mask that integrates a hydrogel matrix with a lipid nanodispersion system designed to simultaneously deliver hydrophilic and hydrophobic active compounds. The key innovation of this formulation lies in the combination of a highly hydrophilic hydrogel structure with lipid nanoparticles embedded within a polymeric network, enabling enhanced bioavailability of active ingredients. Preliminary observations from instrumental measurements in a small group of healthy volunteers suggest that a single 60 min application resulted in notable improvements in skin hydration and elasticity, along with a reduction in transepidermal water loss (TEWL), erythema, and skin sensitivity. Furthermore, both the complete formulation and its individual components exhibited inhibitory activity against collagen and elastin glycation, while promoting type I procollagen synthesis. Importantly, this study provides new evidence for the synergistic interaction between hydrogel matrices and lipid nanodispersion systems in modulating skin barrier function and biochemical aging markers. The formulation, composed entirely of ingredients of natural origin, proved to be an effective carrier for active compounds and showed measurable benefits for skin hydration and barrier-related parameters.
Keywords: alginate hydrogel; lipid nanodispersion; bio-mask; skin hydration; transepidermal water loss (TEWL); skin barrier; procollagen synthesis alginate hydrogel; lipid nanodispersion; bio-mask; skin hydration; transepidermal water loss (TEWL); skin barrier; procollagen synthesis

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MDPI and ACS Style

Miastkowska, M.; Kulawik-Pióro, A.; Sienkiewicz, A.; Łętocha, A.; Malarz, K.; Mrozek-Wilczkiewicz, A.; Bialik-Wąs, K. An Alginate Hydrogel–Lipid Nanodispersion Bio-Mask: A Preliminary Study of Skin Hydration, Barrier Function, and Regenerative Potential. Materials 2026, 19, 2108. https://doi.org/10.3390/ma19102108

AMA Style

Miastkowska M, Kulawik-Pióro A, Sienkiewicz A, Łętocha A, Malarz K, Mrozek-Wilczkiewicz A, Bialik-Wąs K. An Alginate Hydrogel–Lipid Nanodispersion Bio-Mask: A Preliminary Study of Skin Hydration, Barrier Function, and Regenerative Potential. Materials. 2026; 19(10):2108. https://doi.org/10.3390/ma19102108

Chicago/Turabian Style

Miastkowska, Małgorzata, Agnieszka Kulawik-Pióro, Anna Sienkiewicz, Anna Łętocha, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz, and Katarzyna Bialik-Wąs. 2026. "An Alginate Hydrogel–Lipid Nanodispersion Bio-Mask: A Preliminary Study of Skin Hydration, Barrier Function, and Regenerative Potential" Materials 19, no. 10: 2108. https://doi.org/10.3390/ma19102108

APA Style

Miastkowska, M., Kulawik-Pióro, A., Sienkiewicz, A., Łętocha, A., Malarz, K., Mrozek-Wilczkiewicz, A., & Bialik-Wąs, K. (2026). An Alginate Hydrogel–Lipid Nanodispersion Bio-Mask: A Preliminary Study of Skin Hydration, Barrier Function, and Regenerative Potential. Materials, 19(10), 2108. https://doi.org/10.3390/ma19102108

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