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Article

Study on the Flow Field Distribution in Microfluidic Cells for Surface Plasmon Resonance Array Detection

by
Wanwan Chen
1,*,
Jing Li
2,
Peng Wang
1,
Shuai Ma
3 and
Bin Li
1,4
1
Department of Precision Instrument, Tsinghua University, Beijing 100084, China
2
College of Mechanical Engineering, Yangzhou University, Yangzhou 225012, China
3
College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225012, China
4
Research Institute of Tsinghua, Pearl River Delta, Guangzhou 510530, China
*
Author to whom correspondence should be addressed.
Materials 2024, 17(10), 2426; https://doi.org/10.3390/ma17102426
Submission received: 27 March 2024 / Revised: 19 April 2024 / Accepted: 25 April 2024 / Published: 17 May 2024
(This article belongs to the Section Materials Physics)
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Abstract

This research is dedicated to optimizing the design of microfluidic cells to minimize mass transfer effects and ensure a uniform flow field distribution, which is essential for accurate SPR array detection. Employing finite element simulations, this study methodically explored the internal flow dynamics within various microfluidic cell designs to assess the impact of different contact angles on flow uniformity. The cells, constructed from Polydimethylsiloxane (PDMS), were subjected to micro-particle image velocimetry to measure flow velocities in targeted sections. The results demonstrate that a contact angle of 135° achieves the most uniform flow distribution, significantly enhancing the capability for high-throughput array detection. While the experimental results generally corroborated the simulations, minor deviations were observed, likely due to fabrication inaccuracies. The microfluidic cells, evaluated using a custom-built SPR system, showed consistent repeatability.
Keywords: microfluidic cells; SPR array detection; finite element simulation; flow field microfluidic cells; SPR array detection; finite element simulation; flow field

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MDPI and ACS Style

Chen, W.; Li, J.; Wang, P.; Ma, S.; Li, B. Study on the Flow Field Distribution in Microfluidic Cells for Surface Plasmon Resonance Array Detection. Materials 2024, 17, 2426. https://doi.org/10.3390/ma17102426

AMA Style

Chen W, Li J, Wang P, Ma S, Li B. Study on the Flow Field Distribution in Microfluidic Cells for Surface Plasmon Resonance Array Detection. Materials. 2024; 17(10):2426. https://doi.org/10.3390/ma17102426

Chicago/Turabian Style

Chen, Wanwan, Jing Li, Peng Wang, Shuai Ma, and Bin Li. 2024. "Study on the Flow Field Distribution in Microfluidic Cells for Surface Plasmon Resonance Array Detection" Materials 17, no. 10: 2426. https://doi.org/10.3390/ma17102426

APA Style

Chen, W., Li, J., Wang, P., Ma, S., & Li, B. (2024). Study on the Flow Field Distribution in Microfluidic Cells for Surface Plasmon Resonance Array Detection. Materials, 17(10), 2426. https://doi.org/10.3390/ma17102426

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