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Systematic Review

The Adjunctive Use of Leucocyte- and Platelet-Rich Fibrin in Periodontal Endosseous and Furcation Defects: A Systematic Review and Meta-Analysis

1
Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, 115 27 Athens, Greece
2
Bioinformatics and Computational Biology, School of Science, Department of Biology, National and Kapodistrian University of Athens, 157 01 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Bruno Chrcanovic
Materials 2022, 15(6), 2088; https://doi.org/10.3390/ma15062088
Received: 27 January 2022 / Revised: 6 March 2022 / Accepted: 7 March 2022 / Published: 11 March 2022
(This article belongs to the Special Issue Advanced Dental Materials for Periodontal and Bone Regeneration)
The aim of this systematic review of randomized controlled trials was to evaluate the adjunctive use of leucocyte- and platelet-rich fibrin (L-PRF) in periodontal endosseous and furcation defects, as compared without L-PRF. The endosseous defect group was subclassified into: L-PRF/open flap debridement (L-PRF/OFD) versus OFD, L-PRF/osseous graft (L-PRF/OG) versus OG, L-PRF/Emdogain (L-PRF/EMD) versus EMD, and L-PRF/guided tissue regeneration (L-PRF/GTR) versus GTR. The furcation defect group was subclassified into L-PRF/OFD versus OFD, and L-PRF/OG versus OG. Mean difference, 95% confidence intervals and forest plots were calculated for probing pocket depth (PPD), clinical attachment level (CAL) and radiographic defect depth (DD). Nineteen studies concerning systemically healthy non-smokers were included. The results of this systematic review and meta-analysis showed in two- and/or three-wall endosseous defects that the adjunctive use of L-PRF to OFD or OG was significantly beneficial for PPD reduction, CAL gain and DD reduction, as compared without L-PRF. Furthermore, the data showed that for two- and/or three-wall endosseous defects, the adjunctive use of L-PRF to GTR was significantly beneficial for CAL and DD improvement, whereas adding L-PRF to EMD had no significant effect, and that for class II furcation defects, the addition of L-PRF to OFD was significantly beneficial for PPD, CAL and DD improvement, whereas the addition of L-PRF to OG was significantly clinically beneficial. In conclusion, this systematic review and meta-analysis found that there was significant clinical and radiographic additive effectiveness of L-PRF to OFD and to OG in two- and/or three-wall periodontal endosseous defects of systemically healthy non-smokers, as compared without L-PRF. View Full-Text
Keywords: endosseous defects; furcation defects; intrabony defects; L-PRF; platelet-rich fibrin; osseous regeneration; periodontal regeneration; periodontitis; meta-analysis; systematic review endosseous defects; furcation defects; intrabony defects; L-PRF; platelet-rich fibrin; osseous regeneration; periodontal regeneration; periodontitis; meta-analysis; systematic review
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MDPI and ACS Style

Pepelassi, E.; Deligianni, M. The Adjunctive Use of Leucocyte- and Platelet-Rich Fibrin in Periodontal Endosseous and Furcation Defects: A Systematic Review and Meta-Analysis. Materials 2022, 15, 2088. https://doi.org/10.3390/ma15062088

AMA Style

Pepelassi E, Deligianni M. The Adjunctive Use of Leucocyte- and Platelet-Rich Fibrin in Periodontal Endosseous and Furcation Defects: A Systematic Review and Meta-Analysis. Materials. 2022; 15(6):2088. https://doi.org/10.3390/ma15062088

Chicago/Turabian Style

Pepelassi, Eudoxie, and Maria Deligianni. 2022. "The Adjunctive Use of Leucocyte- and Platelet-Rich Fibrin in Periodontal Endosseous and Furcation Defects: A Systematic Review and Meta-Analysis" Materials 15, no. 6: 2088. https://doi.org/10.3390/ma15062088

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