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Volume 15
Issue 12
10.3390/ma15124111
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Article

Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs

by
Patrick Rider
1,2,†,
Željka Perić Kačarević
1,2,3,†,
Akiva Elad
2,
Daniel Rothamel
4,
Gerrit Sauer
4,
Fabien Bornert
5,
Peter Windisch
6,
Dávid Hangyási
6,
Balint Molnar
6,
Bernhard Hesse
7,
Michel Assad
8 and
Frank Witte
1,*
1
Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité–Universitätsmedizin Berlin, Aßmannshauser Straße 4–6, 14197 Berlin, Germany
2
Botiss Biomaterials AG, Ullsteinstrasse 108, 12109 Berlin, Germany
3
Department of Anatomy Histology, Embryology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health, University of Osijek, 31000 Osijek, Croatia
4
CMF Surgery, Johannes BLA Hospital, 41239 Mönchengladbach, Germany
5
Faculté de Chirurgie Dentaire de Strasbourg, Université de Strasbourg, 8 Rue Sainte-Elisabeth, 67000 Strasbourg, France
6
Department of Periodontology, Semmelweis University, 1769 Budapest, Hungary
7
Xploraytion GmbH, Bismarkstrasse 11, 10625 Berlin, Germany
8
Medical Device Preclinical Services, Charles River Laboratories, 1635 Lionel-Bertrand Blvd., Boisbriand, QC J7H 1N8, Canada
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Materials 2022, 15(12), 4111; https://doi.org/10.3390/ma15124111
Submission received: 6 May 2022 / Revised: 3 June 2022 / Accepted: 8 June 2022 / Published: 9 June 2022
(This article belongs to the Special Issue Biomaterials in Conservative Dentistry)
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Abstract

Nowadays, the most commonly used fixation systems are non-resorbable, but new resorbable magnesium alloy fixation screws have been introduced recently. Therefore, the aim of this study was to compare the magnesium fixation screw and the commonly used non-resorbable titanium screw in an animal model. Four 3-wall defect sites were covered with collagen membranes in the mandible of twenty beagle dogs (two sites on the left and two on the right). Each membrane was fixed with either four magnesium screws or four titanium screws. Post-operative follow-up revealed the expected observations such as transient inflammation and pain. Both groups showed a good healing response, with no differences between groups. Micro-CT analysis showed no significant difference between groups in terms of BV/TV or soft tissue volume. The void volume in the magnesium fixation screw group continued to decrease on average between the different timepoints, but not significantly. Furthermore, a gradual progression of the degradation process of the magnesium screws was observed in the same group. Magnesium screws and titanium screws showed equal performance in tissue regeneration according to GBR principles. An additional advantage of magnesium screws is their resorbable nature, which eliminates the need for a second surgical step to remove the screws.
Keywords: magnesium fixation screws; beagle dog model GBR; healing; degradation; micro-CT magnesium fixation screws; beagle dog model GBR; healing; degradation; micro-CT

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MDPI and ACS Style

Rider, P.; Kačarević, Ž.P.; Elad, A.; Rothamel, D.; Sauer, G.; Bornert, F.; Windisch, P.; Hangyási, D.; Molnar, B.; Hesse, B.; et al. Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs. Materials 2022, 15, 4111. https://doi.org/10.3390/ma15124111

AMA Style

Rider P, Kačarević ŽP, Elad A, Rothamel D, Sauer G, Bornert F, Windisch P, Hangyási D, Molnar B, Hesse B, et al. Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs. Materials. 2022; 15(12):4111. https://doi.org/10.3390/ma15124111

Chicago/Turabian Style

Rider, Patrick, Željka Perić Kačarević, Akiva Elad, Daniel Rothamel, Gerrit Sauer, Fabien Bornert, Peter Windisch, Dávid Hangyási, Balint Molnar, Bernhard Hesse, and et al. 2022. "Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs" Materials 15, no. 12: 4111. https://doi.org/10.3390/ma15124111

APA Style

Rider, P., Kačarević, Ž. P., Elad, A., Rothamel, D., Sauer, G., Bornert, F., Windisch, P., Hangyási, D., Molnar, B., Hesse, B., Assad, M., & Witte, F. (2022). Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs. Materials, 15(12), 4111. https://doi.org/10.3390/ma15124111

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