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Article

Raman Spectroscopic Study of TiO2 Nanoparticles’ Effects on the Hemoglobin State in Individual Red Blood Cells

1
Department of Physics, National Dong Hwa University, Hualien 974301, Taiwan
2
P.N. Lebedev Physical Institute of Russian Academy of Sciences, 119991 Moscow, Russia
3
Department of Physics, Moscow State University, 119991 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Academic Editors: Valery V. Tuchin and Malgorzata Szczerska
Materials 2021, 14(20), 5920; https://doi.org/10.3390/ma14205920
Received: 1 September 2021 / Revised: 28 September 2021 / Accepted: 6 October 2021 / Published: 9 October 2021
(This article belongs to the Special Issue Advanced Materials for Biophotonics Applications)
Titanium dioxide (TiO2) is considered to be a nontoxic material and is widely used in a number of everyday products, such as sunscreen. TiO2 nanoparticles (NP) are also considered as prospective agents for photodynamic therapy and drug delivery. These applications require an understanding of the potential effects of TiO2 on the blood system and its components upon administration. In the presented work, we analyze the interaction of TiO2 nanoparticles of different crystal phases (anatase and rutile) with individual rat Red Blood Cells (RBC) and the TiO2 influence on the oxygenation state and functionality of RBC, estimated via analysis of Raman spectra of Hemoglobin (Hb) and their distribution along individual RBC. Raman spectral signals also allow localization of the TiO2 NP on the RBC. No penetration of the NP inside RBC was observed; however, both kinds of TiO2 NP adsorbed on the RBC membrane can affect the Hb state. Mechanisms involving the NP–membrane–Hb interaction, resulting in partial deoxygenation of Hb and TiO2 photothermal effect on Hb under Raman laser excitation, are suggested. The possible influence on the safety of TiO2 use in advanced medical application, especially on the safety and efficiency of photothermal therapy, is discussed. View Full-Text
Keywords: red blood cell; hemoglobin; titanium dioxide nanoparticles; Raman spectroscopy; Raman mapping red blood cell; hemoglobin; titanium dioxide nanoparticles; Raman spectroscopy; Raman mapping
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MDPI and ACS Style

Perevedentseva, E.; Lin, Y.-C.; Karmenyan, A.; Wu, K.-T.; Lugovtsov, A.; Shirshin, E.; Priezzhev, A.; Cheng, C.-L. Raman Spectroscopic Study of TiO2 Nanoparticles’ Effects on the Hemoglobin State in Individual Red Blood Cells. Materials 2021, 14, 5920. https://doi.org/10.3390/ma14205920

AMA Style

Perevedentseva E, Lin Y-C, Karmenyan A, Wu K-T, Lugovtsov A, Shirshin E, Priezzhev A, Cheng C-L. Raman Spectroscopic Study of TiO2 Nanoparticles’ Effects on the Hemoglobin State in Individual Red Blood Cells. Materials. 2021; 14(20):5920. https://doi.org/10.3390/ma14205920

Chicago/Turabian Style

Perevedentseva, Elena, Yu-Chung Lin, Artashes Karmenyan, Kuan-Ting Wu, Andrei Lugovtsov, Evgeny Shirshin, Alexander Priezzhev, and Chia-Liang Cheng. 2021. "Raman Spectroscopic Study of TiO2 Nanoparticles’ Effects on the Hemoglobin State in Individual Red Blood Cells" Materials 14, no. 20: 5920. https://doi.org/10.3390/ma14205920

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