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Article

Tearable and Fillable Composite Sponges Capable of Heat Generation and Drug Release in Response to Alternating Magnetic Field

1
Department of Biomaterials, Faculty of Dental Science, Kyushu University3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
2
Department of Materials Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
*
Author to whom correspondence should be addressed.
Materials 2020, 13(16), 3637; https://doi.org/10.3390/ma13163637
Received: 16 July 2020 / Revised: 13 August 2020 / Accepted: 14 August 2020 / Published: 17 August 2020
(This article belongs to the Special Issue Advanced Composite Biomaterials)
Tearable and fillable implants are used to facilitate surgery. The use of implants that can generate heat and release a drug in response to an exogenous trigger, such as an alternating magnetic field (AMF), can facilitate on-demand combined thermal treatment and chemotherapy via remote operation. In this study, we fabricated tearable sponges composed of collagen, magnetite nanoparticles, and anticancer drugs. Crosslinking of the sponges by heating for 6 h completely suppressed undesirable drug release in saline at 37 °C but allowed drug release at 45 °C. The sponges generated heat immediately after AMF application and raised the cell culture medium temperature from 37 to 45 °C within 15 min. Heat generation was controlled by switching the AMF on and off. Furthermore, in response to heat generation, drug release from the sponges could be induced and moderated. Thus, remote-controlled heat generation and drug release were achieved by switching the AMF on and off. The sponges destroyed tumor cells when AMF was applied for 15 min but not when AMF was absent. The tearing and filling properties of the sponges may be useful for the surgical repair of bone and tissue defects. Moreover, these sponges, along with AMF application, can facilitate combined thermal therapy and chemotherapy. View Full-Text
Keywords: magnetic nanoparticles; composite; DDS; hyperthermia; collagen magnetic nanoparticles; composite; DDS; hyperthermia; collagen
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MDPI and ACS Style

Hayashi, K.; Tokuda, A.; Nakamura, J.; Sugawara-Narutaki, A.; Ohtsuki, C. Tearable and Fillable Composite Sponges Capable of Heat Generation and Drug Release in Response to Alternating Magnetic Field. Materials 2020, 13, 3637. https://doi.org/10.3390/ma13163637

AMA Style

Hayashi K, Tokuda A, Nakamura J, Sugawara-Narutaki A, Ohtsuki C. Tearable and Fillable Composite Sponges Capable of Heat Generation and Drug Release in Response to Alternating Magnetic Field. Materials. 2020; 13(16):3637. https://doi.org/10.3390/ma13163637

Chicago/Turabian Style

Hayashi, Koichiro, Atsuto Tokuda, Jin Nakamura, Ayae Sugawara-Narutaki, and Chikara Ohtsuki. 2020. "Tearable and Fillable Composite Sponges Capable of Heat Generation and Drug Release in Response to Alternating Magnetic Field" Materials 13, no. 16: 3637. https://doi.org/10.3390/ma13163637

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