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Open AccessArticle

Fluorescence-Based Analysis of Noncanonical Functions of Aminoacyl-tRNA Synthetase-Interacting Multifunctional Proteins (AIMPs) in Peripheral Nerves

1
Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
2
Department of Biomedical Science, Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, Graduation School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
3
Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, 262, Gamcheon-ro, Seo-gu, Busan 49267, Korea
4
Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, 32, Daesingongwon-ro, Seo-gu, Busan 49201, Korea
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(7), 1064; https://doi.org/10.3390/ma12071064
Received: 12 March 2019 / Revised: 25 March 2019 / Accepted: 28 March 2019 / Published: 1 April 2019
(This article belongs to the Special Issue Fluorescent Probes for Imaging and Detection)
Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs) are auxiliary factors involved in protein synthesis related to aminoacyl-tRNA synthetases (ARSs). AIMPs, which are well known as nonenzymatic factors, include AIMP1/p43, AIMP2/p38, and AIMP3/p18. The canonical functions of AIMPs include not only protein synthesis via multisynthetase complexes but also maintenance of the structural stability of these complexes. Several recent studies have demonstrated nontypical (noncanonical) functions of AIMPs, such as roles in apoptosis, inflammatory processes, DNA repair, and so on. However, these noncanonical functions of AIMPs have not been studied in peripheral nerves related to motor and sensory functions. Peripheral nerves include two types of structures: peripheral axons and Schwann cells. The myelin sheath formed by Schwann cells produces saltatory conduction, and these rapid electrical signals control motor and sensory functioning in the service of survival in mammals. Schwann cells play roles not only in myelin sheath formation but also as modulators of nerve degeneration and regeneration. Therefore, it is important to identify the main functions of Schwann cells in peripheral nerves. Here, using immunofluorescence technique, we demonstrated that AIMPs are essential morphological indicators of peripheral nerve degeneration, and their actions are limited to peripheral nerves and not the dorsal root ganglion and the ventral horn of the spinal cord. View Full-Text
Keywords: aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs); Schwann cells; Wallerian degeneration; noncanonical functions; fluorescence-based analysis aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs); Schwann cells; Wallerian degeneration; noncanonical functions; fluorescence-based analysis
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MDPI and ACS Style

Kim, M.; Kim, H.; Kim, D.; Park, C.; Huh, Y.; Jung, J.; Chung, H.-J.; Jeong, N.Y. Fluorescence-Based Analysis of Noncanonical Functions of Aminoacyl-tRNA Synthetase-Interacting Multifunctional Proteins (AIMPs) in Peripheral Nerves. Materials 2019, 12, 1064.

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