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Open AccessCommunication

A Selective Fluorescence Turn-On Probe for the Detection of DCNP (Nerve Agent Tabun Simulant)

by 1 and 1,2,3,4,*
1
Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea
2
Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea
3
Center for Converging Humanities, Kyung Hee University, Seoul 02447, Korea
4
Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea
*
Author to whom correspondence should be addressed.
Materials 2019, 12(18), 2943; https://doi.org/10.3390/ma12182943
Received: 1 August 2019 / Revised: 30 August 2019 / Accepted: 9 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue Fluorescent Probes for Imaging and Detection)
Diethylcyanophosphonate (DCNP) is a simulant of Tabun (GA) which is an extremely toxic chemical substance and is used as a chemical warfare (CW) nerve agent. Due to its toxic properties, monitoring methods have been constantly come under the spotlight. What we are proposing within this report is a next-generation fluorescent probe, DMHN1, which allows DCNP to become fully traceable in a sensitive, selective, and responsive manner. This is the first fluorescent turn-on probe within the dipolar naphthalene platform induced by ESIPT (excited state intramolecular proton transfer) suppression that allows us to sense DCNP without any disturbance by other similar G-series chemical weapons. The successful demonstrations of practical applications, such as in vitro analysis, soil analysis, and the development of an on-site real-time prototype sensing kit, encourage further applications in a variety of fields. View Full-Text
Keywords: molecular probe; reaction-based probe; diethylcyanophosphonate; nerve agent; real-time detection molecular probe; reaction-based probe; diethylcyanophosphonate; nerve agent; real-time detection
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MDPI and ACS Style

Jung, Y.; Kim, D. A Selective Fluorescence Turn-On Probe for the Detection of DCNP (Nerve Agent Tabun Simulant). Materials 2019, 12, 2943.

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