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Open AccessFeature PaperArticle

Drug Release Kinetics of Electrospun PHB Meshes

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Department of Food Chemistry and Biotechnology, Faculty of Chemistry, Brno University of Technology, Purkynova 118, 612 00 Brno, Czech Republic
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Department of Physical and Applied Chemistry, Faculty of Chemistry, Brno University of Technology, Purkynova 118, 612 00 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Materials 2019, 12(12), 1924; https://doi.org/10.3390/ma12121924
Received: 12 May 2019 / Revised: 11 June 2019 / Accepted: 13 June 2019 / Published: 14 June 2019
(This article belongs to the Special Issue Biocompatible and Biodegradable 3D Scaffolds)
Microbial poly(3-hydroxybutyrate) (PHB) has several advantages including its biocompatibility and ability to degrade in vivo and in vitro without toxic substances. This paper investigates the feasibility of electrospun PHB meshes serving as drug delivery systems. The morphology of the electrospun samples was modified by varying the concentration of PHB in solution and the solvent composition. Scanning electron microscopy of the electrospun PHB scaffolds revealed the formation of different morphologies including porous, filamentous/beaded and fiber structures. Levofloxacin was used as the model drug for incorporation into PHB electrospun meshes. The entrapment efficiency was found to be dependent on the viscosity of the PHB solution used for electrospinning and ranged from 14.4–81.8%. The incorporation of levofloxacin in electrospun meshes was confirmed by Fourier-transform infrared spectroscopy and UV-VIS spectroscopy. The effect of the morphology of the electrospun meshes on the levofloxacin release profile was screened in vitro in phosphate-buffered saline solution. Depending upon the morphology, the electrospun meshes released about 14–20% of levofloxacin during the first 24 h. The percentage of drug released after 13 days increased up to 32.4% and was similar for all tested morphologies. The antimicrobial efficiency of all tested samples independent of the morphology, was confirmed by agar diffusion testing. View Full-Text
Keywords: biomaterials; electrospinning; drug release kinetics; levofloxacin; morphology; poly(3-hydroxybutyrate); scaffolds biomaterials; electrospinning; drug release kinetics; levofloxacin; morphology; poly(3-hydroxybutyrate); scaffolds
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MDPI and ACS Style

Kundrat, V.; Cernekova, N.; Kovalcik, A.; Enev, V.; Marova, I. Drug Release Kinetics of Electrospun PHB Meshes. Materials 2019, 12, 1924.

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