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Optimization and Characterization of Paper-Made Surface Enhanced Raman Scattering (SERS) Substrates with Au and Ag NPs for Quantitative Analysis
Open AccessFeature PaperArticle

TopUp SERS Substrates with Integrated Internal Standard

Leibniz Institute of Photonic Technology e. V. (IPHT), Albert-Einstein-Str. 9, 07745 Jena, Germany
Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Helmholtzweg 4, 07743 Jena, Germany
Authors to whom correspondence should be addressed.
Materials 2018, 11(2), 325;
Received: 11 December 2017 / Revised: 12 February 2018 / Accepted: 20 February 2018 / Published: 24 February 2018
(This article belongs to the Special Issue SERS-Active Substrates)
Surface-enhanced Raman spectroscopy (SERS) is known as a molecular-specific and highly sensitive method. In order to enable the routine application of SERS, powerful SERS substrates are of great importance. Within this manuscript, a TopUp SERS substrate is introduced which is fabricated by a top-down process based on microstructuring as well as a bottom-up generation of silver nanostructures. The Raman signal of the support material acts as an internal standard in order to improve the quantification capabilities. The analyte molecule coverage of sulfamethoxazole on the surface of the nanostructures is characterized by the SERS signal evolution fitted by a Langmuir–Freundlich isotherm. View Full-Text
Keywords: SERS; TopUp SERS substrate; sulfamethoxazole; Langmuir–Freundlich isotherm SERS; TopUp SERS substrate; sulfamethoxazole; Langmuir–Freundlich isotherm
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Patze, S.; Huebner, U.; Weber, K.; Cialla-May, D.; Popp, J. TopUp SERS Substrates with Integrated Internal Standard. Materials 2018, 11, 325.

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