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Open AccessReview

Fe3O4 Nanoparticles in Targeted Drug/Gene Delivery Systems

by Lazhen Shen 1,*, Bei Li 1 and Yongsheng Qiao 2,*
1
School of Chemistry and Environmental Engineering, Institute of Applied Chemistry, Shanxi Datong University, Datong 037009, China
2
Department of Chemistry, Xinzhou Teachers University, Xinzhou 034000, China
*
Authors to whom correspondence should be addressed.
Materials 2018, 11(2), 324; https://doi.org/10.3390/ma11020324
Received: 31 January 2018 / Revised: 21 February 2018 / Accepted: 21 February 2018 / Published: 23 February 2018
Fe3O4 nanoparticles (NPs), the most traditional magnetic nanoparticles, have received a great deal of attention in the biomedical field, especially for targeted drug/gene delivery systems, due to their outstanding magnetism, biocompatibility, lower toxicity, biodegradability, and other features. Naked Fe3O4 NPs are easy to aggregate and oxidize, and thus are often made with various coatings to realize superior properties for targeted drug/gene delivery. In this review, we first list the three commonly utilized synthesis methods of Fe3O4 NPs, and their advantages and disadvantages. In the second part, we describe coating materials that exhibit noticeable features that allow functionalization of Fe3O4 NPs and summarize their methods of drug targeting/gene delivery. Then our efforts will be devoted to the research status and progress of several different functionalized Fe3O4 NP delivery systems loaded with chemotherapeutic agents, and we present targeted gene transitive carriers in detail. In the following section, we illuminate the most effective treatment systems of the combined drug and gene therapy. Finally, we propose opportunities and challenges of the clinical transformation of Fe3O4 NPs targeting drug/gene delivery systems. View Full-Text
Keywords: Fe3O4 nanoparticles; synthesis; functionalization; coating; drug/gene delivery systems Fe3O4 nanoparticles; synthesis; functionalization; coating; drug/gene delivery systems
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Shen, L.; Li, B.; Qiao, Y. Fe3O4 Nanoparticles in Targeted Drug/Gene Delivery Systems. Materials 2018, 11, 324.

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