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Materials 2018, 11(2), 229;

Efficacy of Octacalcium Phosphate Collagen Composite for Titanium Dental Implants in Dogs

Division of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan
Toyobo Co., Ltd., Otsu 520-0292, Japan
Division of Bone Regenerative Engineering, Tohoku University Graduate School of Biomedical Engineering, Sendai 980-8574, Japan
Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan
Author to whom correspondence should be addressed.
Received: 9 January 2018 / Revised: 25 January 2018 / Accepted: 30 January 2018 / Published: 2 February 2018
(This article belongs to the Special Issue Bone Substitute Materials)
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Background: Previous studies showed that octacalcium (OCP) collagen composite (OCP/Col) can be used to repair human jaw bone defects without any associated abnormalities. The present study investigated whether OCP/Col could be applied to dental implant treatment using a dog tooth extraction socket model. Methods: The premolars of dogs were extracted; each extraction socket was extended, and titanium dental implants were placed in each socket. OCP/Col was inserted in the space around a titanium dental implant. Autologous bone was used to fill the other sockets, while the untreated socket (i.e., no bone substitute material) served as a control. Three months after the operation, these specimens were analyzed for the osseointegration of each bone substitute material with the surface of the titanium dental implant. Results: In histomorphometric analyses, the peri-implant bone areas (BA%) and bone-implant contact (BIC%) were measured. There was no difference in BA% or BIC% between OCP/Col and autologous bone. Conclusion: These results suggested that OCP/Col could be used for implant treatment as a bone substitute. View Full-Text
Keywords: bone substitute; osseointegration; dental implant bone substitute; osseointegration; dental implant

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Kawai, T.; Matsui, K.; Ezoe, Y.; Kajii, F.; Suzuki, O.; Takahashi, T.; Kamakura, S. Efficacy of Octacalcium Phosphate Collagen Composite for Titanium Dental Implants in Dogs. Materials 2018, 11, 229.

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