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Article

Understanding Drug Release Data through Thermodynamic Analysis

by
Marjorie Caroline Liberato Cavalcanti Freire
1,
Francisco Alexandrino
2,
Henrique Rodrigues Marcelino
3,
Paulo Henrique de Souza Picciani
4,
Kattya Gyselle de Holanda e Silva
5,
Julieta Genre
3,
Anselmo Gomes de Oliveira
6 and
Eryvaldo Sócrates Tabosa do Egito
1,2,3,*
1
Faculdade de Farmácia, Universidade Federal do Rio Grande do Norte, Natal-RN 59012-570, Brazil
2
Programa de Pós-graduaçãoem Nanotecnologia Farmacêutica, Universidade Federal do Rio Grande do Norte, Natal-RN 59012-570, Brazil
3
Programa de Pós-graduaçãoem Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal-RN 59012-570, Brazil
4
Instituto de Macromoléculas Eloisa Mano, Universidade Federal do Rio de Janeiro, Rio de Janeiro-RJ 21941-598, Brazil
5
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro-RJ 21949-900, Brazil
6
Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara-SP 14800-903, Brazil
*
Author to whom correspondence should be addressed.
Materials 2017, 10(6), 651; https://doi.org/10.3390/ma10060651
Submission received: 22 March 2017 / Revised: 13 May 2017 / Accepted: 18 May 2017 / Published: 13 June 2017
(This article belongs to the Section Biomaterials)
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Abstract

Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas–Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability.
Keywords: Amphotericin B; drug release; kinetic profile; thermodynamics; hydrogels; films; nanofibers Amphotericin B; drug release; kinetic profile; thermodynamics; hydrogels; films; nanofibers
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MDPI and ACS Style

Freire, M.C.L.C.; Alexandrino, F.; Marcelino, H.R.; Picciani, P.H.d.S.; Silva, K.G.d.H.e.; Genre, J.; Oliveira, A.G.d.; Egito, E.S.T.d. Understanding Drug Release Data through Thermodynamic Analysis. Materials 2017, 10, 651. https://doi.org/10.3390/ma10060651

AMA Style

Freire MCLC, Alexandrino F, Marcelino HR, Picciani PHdS, Silva KGdHe, Genre J, Oliveira AGd, Egito ESTd. Understanding Drug Release Data through Thermodynamic Analysis. Materials. 2017; 10(6):651. https://doi.org/10.3390/ma10060651

Chicago/Turabian Style

Freire, Marjorie Caroline Liberato Cavalcanti, Francisco Alexandrino, Henrique Rodrigues Marcelino, Paulo Henrique de Souza Picciani, Kattya Gyselle de Holanda e Silva, Julieta Genre, Anselmo Gomes de Oliveira, and Eryvaldo Sócrates Tabosa do Egito. 2017. "Understanding Drug Release Data through Thermodynamic Analysis" Materials 10, no. 6: 651. https://doi.org/10.3390/ma10060651

APA Style

Freire, M. C. L. C., Alexandrino, F., Marcelino, H. R., Picciani, P. H. d. S., Silva, K. G. d. H. e., Genre, J., Oliveira, A. G. d., & Egito, E. S. T. d. (2017). Understanding Drug Release Data through Thermodynamic Analysis. Materials, 10(6), 651. https://doi.org/10.3390/ma10060651

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