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Open AccessFeature PaperArticle

The In Vitro Bioactivity, Degradation, and Cytotoxicity of Polymer-Derived Wollastonite-Diopside Glass-Ceramics

Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas, Federal University of ABC, Santo André 09210-580, Brazil
Dipartimento di Ingegneria Industriale, University of Padova, Padova 35131, Italy
Ceramics Department, National Research Centre, El-Bohous Street, 12622 Cairo, Egypt
Departamento de Ciências, State University of Maringá, Maringá 87360-000, Brazil
Authors to whom correspondence should be addressed.
Academic Editor: Aldo R. Boccaccini
Materials 2017, 10(4), 425;
Received: 16 December 2016 / Revised: 24 March 2017 / Accepted: 12 April 2017 / Published: 18 April 2017
(This article belongs to the Special Issue Bioceramics 2016)
Ca-Mg silicates are receiving a growing interest in the field of bioceramics. In a previous study, wollastonite-diopside (WD) glass-ceramics were successfully prepared by a new processing route, consisting of the heat treatment of a silicone resin embedding reactive oxide particles and a Ca/Mg-rich glass. The in vitro degradation, bioactivity, and cell response of these new WD glass-ceramics, fired at 900–1100 °C for 1 h, as a function of the Ca/Mg-rich glass content, are the aim of this investigation The results showed that WD glass-ceramics from formulations comprising different glass contents (70–100% at 900 °C, 30% at 1100 °C) exhibit the formation of an apatite-like layer on their surface after immersion in SBF for seven days, thus confirming their surface bioactivity. The XRD results showed that these samples crystallized, mainly forming wollastonite (CaSiO3) and diopside (CaMgSi2O6), but combeite (Na2Ca2Si3O9) crystalline phase was also detected. Besides in vitro bioactivity, cytotoxicity and osteoblast adhesion and proliferation tests were applied after all characterizations, and the formulation comprising 70% glass was demonstrated to be promising for further in vivo studies. View Full-Text
Keywords: glass-ceramics; polymer-derived ceramics; bioactivity; cytotoxicity glass-ceramics; polymer-derived ceramics; bioactivity; cytotoxicity
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Juraski, A.D.C.; Rodas, A.C.D.; Elsayed, H.; Bernardo, E.; Soares, V.O.; Daguano, J. The In Vitro Bioactivity, Degradation, and Cytotoxicity of Polymer-Derived Wollastonite-Diopside Glass-Ceramics. Materials 2017, 10, 425.

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