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Open AccessArticle

Textural, Structural and Biological Evaluation of Hydroxyapatite Doped with Zinc at Low Concentrations

National Institute of Materials Physics, P.O. Box MG 07, 07725 Magurele, Romania
CNRS, Laboratoire de Chimie et Biologie des Métaux (LCBM) UMR 5249 CNRS-CEA-UJF, F-38054 Grenoble, France
CEA, LCBM, F-38054 Grenoble, France
LCBM, University Grenoble Alpes, LCBM, F-38054 Grenoble, France
HORIBA Jobin Yvon S.A.S., 6-18, rue du Canal, 91165 Longjumeau Cédex, France
Emergency Hospital Floreasca Bucharest, 8 Calea Floresca, Sector 1, 014461 Bucharest, Romania
Surgery Department, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, Romania
Author to whom correspondence should be addressed.
Academic Editor: Tobias Fey
Materials 2017, 10(3), 229;
Received: 23 January 2017 / Revised: 19 February 2017 / Accepted: 22 February 2017 / Published: 25 February 2017
(This article belongs to the Special Issue Porous Ceramics)
The present work was focused on the synthesis and characterization of hydroxyapatite doped with low concentrations of zinc (Zn:HAp) (0.01 < xZn < 0.05). The incorporation of low concentrations of Zn2+ ions in the hydroxyapatite (HAp) structure was achieved by co-precipitation method. The physico-chemical properties of the samples were characterized by X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), Scanning Electron Microscopy (SEM), zeta-potential, and DLS and N2-BET measurements. The results obtained by XRD and FTIR studies demonstrated that doping hydroxyapatite with low concentrations of zinc leads to the formation of a hexagonal structure with lattice parameters characteristic to hydroxyapatite. The XRD studies have also shown that the crystallite size and lattice parameters of the unit cell depend on the substitutions of Ca2+ with Zn2+ in the apatitic structure. Moreover, the FTIR analysis revealed that the water content increases with the increase of zinc concentration. Furthermore, the Energy Dispersive X-ray Analysis (EDAX) and XPS analyses showed that the elements Ca, P, O, and Zn were found in all the Zn:HAp samples suggesting that the synthesized materials were zinc doped hydroxyapatite, Ca10−xZnx(PO4)6(OH), with 0.01 ≤ xZn ≤ 0.05. Antimicrobial assays on Staphylococcus aureus and Escherichia coli bacterial strains and HepG2 cell viability assay were carried out. View Full-Text
Keywords: zinc; hydroxyapatite; Staphylococcus aureus; Escherichia coli; HepG2 cell viability zinc; hydroxyapatite; Staphylococcus aureus; Escherichia coli; HepG2 cell viability
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MDPI and ACS Style

Predoi, D.; Iconaru, S.L.; Deniaud, A.; Chevallet, M.; Michaud-Soret, I.; Buton, N.; Prodan, A.M. Textural, Structural and Biological Evaluation of Hydroxyapatite Doped with Zinc at Low Concentrations. Materials 2017, 10, 229.

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