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Volume 31
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10.3390/curroncol31060227
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Article

Long-Term Oncologic Outcomes of Off-Clamp Robotic Partial Nephrectomy for Cystic Renal Tumors: A Propensity Score Matched-Pair Comparison of Cystic versus Pure Clear Cell Carcinoma

by
Mariaconsiglia Ferriero
1,*,
Alberto Ragusa
2,
Riccardo Mastroianni
1,
Gabriele Tuderti
1,
Manuela Costantini
1,
Umberto Anceschi
1,
Leonardo Misuraca
1,
Aldo Brassetti
1,
Salvatore Guaglianone
1,
Alfredo Maria Bove
1,
Costantino Leonardo
1,
Michele Gallucci
1,
Rocco Papalia
2 and
Giuseppe Simone
1
1
Department of Urology, IRCCS “Regina Elena” National Cancer Institute, 00144 Rome, Italy
2
Department of Urology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2024, 31(6), 2985-2993; https://doi.org/10.3390/curroncol31060227
Submission received: 23 March 2024 / Revised: 4 May 2024 / Accepted: 13 May 2024 / Published: 27 May 2024
(This article belongs to the Section Genitourinary Oncology)
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Abstract

Few data are available on survival outcomes of partial nephrectomy performed for cystic renal tumors. We present the first long-term oncological outcomes of cystic (cystRCC) versus pure clear cell renal cell carcinoma (ccRCC) in a propensity score-matched (PSM) analysis. Our “renal cancer” prospectively maintained database was queried for “cystRCC” or “ccRCC” and “off-clamp robotic partial nephrectomy” (off-C RPN). The two groups were compared for age, gender, tumor size, pT stage, and Fuhrman grade. A 1:3 PSM analysis was applied to reduce covariate imbalance to <10% and two homogeneous populations were generated. Student t- and Chi-square tests were used for continuous and categorical variables, respectively. Ten-year oncological outcomes were compared between the two cohorts using log-rank test. Univariable Cox regression analysis was used to identify predictors of disease progression after RPN. Out of 859 off-C RPNs included, 85 cases were cystRCC and 774 were ccRCC at histologic evaluation. After applying the PSM analysis, two cohorts were selected, including 64 cystRCC and 170 ccRCC. Comparable 10-year cancer-specific survival probability (95.3% versus 100%, p = 0.146) was found between the two cohorts. Conversely, 10-year disease-free survival probability (DFS) was less favorable for pure ccRCC than cystRCC (66.69% versus 90.1%, p = 0.035). At univariable regression analysis, ccRCC histology was the only independent predictor of DFS probability (HR 2.96 95% CI 1.03–8.47, p = 0.044). At the 10-year evaluation, cystRCC showed favorable oncological outcomes after off-C RPN. Pure clear cell variant histology displayed a higher rate of disease recurrence than cystic lesions.
Keywords: cystic renal tumors; robotic surgery; nephron-sparing surgery; off-clamp partial nephrectomy; oncological outcomes cystic renal tumors; robotic surgery; nephron-sparing surgery; off-clamp partial nephrectomy; oncological outcomes

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MDPI and ACS Style

Ferriero, M.; Ragusa, A.; Mastroianni, R.; Tuderti, G.; Costantini, M.; Anceschi, U.; Misuraca, L.; Brassetti, A.; Guaglianone, S.; Bove, A.M.; et al. Long-Term Oncologic Outcomes of Off-Clamp Robotic Partial Nephrectomy for Cystic Renal Tumors: A Propensity Score Matched-Pair Comparison of Cystic versus Pure Clear Cell Carcinoma. Curr. Oncol. 2024, 31, 2985-2993. https://doi.org/10.3390/curroncol31060227

AMA Style

Ferriero M, Ragusa A, Mastroianni R, Tuderti G, Costantini M, Anceschi U, Misuraca L, Brassetti A, Guaglianone S, Bove AM, et al. Long-Term Oncologic Outcomes of Off-Clamp Robotic Partial Nephrectomy for Cystic Renal Tumors: A Propensity Score Matched-Pair Comparison of Cystic versus Pure Clear Cell Carcinoma. Current Oncology. 2024; 31(6):2985-2993. https://doi.org/10.3390/curroncol31060227

Chicago/Turabian Style

Ferriero, Mariaconsiglia, Alberto Ragusa, Riccardo Mastroianni, Gabriele Tuderti, Manuela Costantini, Umberto Anceschi, Leonardo Misuraca, Aldo Brassetti, Salvatore Guaglianone, Alfredo Maria Bove, and et al. 2024. "Long-Term Oncologic Outcomes of Off-Clamp Robotic Partial Nephrectomy for Cystic Renal Tumors: A Propensity Score Matched-Pair Comparison of Cystic versus Pure Clear Cell Carcinoma" Current Oncology 31, no. 6: 2985-2993. https://doi.org/10.3390/curroncol31060227

APA Style

Ferriero, M., Ragusa, A., Mastroianni, R., Tuderti, G., Costantini, M., Anceschi, U., Misuraca, L., Brassetti, A., Guaglianone, S., Bove, A. M., Leonardo, C., Gallucci, M., Papalia, R., & Simone, G. (2024). Long-Term Oncologic Outcomes of Off-Clamp Robotic Partial Nephrectomy for Cystic Renal Tumors: A Propensity Score Matched-Pair Comparison of Cystic versus Pure Clear Cell Carcinoma. Current Oncology, 31(6), 2985-2993. https://doi.org/10.3390/curroncol31060227

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