Next Article in Journal
Prognostic Relevance of PDL1 and CA19-9 Expression in Gallbladder Cancer vs. Inflammatory Lesions
Previous Article in Journal
Mitigating Breast-Cancer-Related Lymphedema—A Calgary Program for Immediate Lymphatic Reconstruction (ILR)
Previous Article in Special Issue
Efficacy and Feasibility of Proton Beam Therapy in Relapsed High-Risk Neuroblastoma-Experiences from the Prospective KiProReg Registry
 
 
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

A Retrospective Study of Renal Growth Changes after Proton Beam Therapy for Pediatric Malignant Tumor

1
Department of Radiation Oncology, University of Tsukuba Hospital, Tsukuba 305-8576, Japan
2
Department of Pediatrics, University of Tsukuba Hospital, Tsukuba 305-8576, Japan
3
Department of Biostatistics, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2023, 30(2), 1560-1570; https://doi.org/10.3390/curroncol30020120
Received: 28 November 2022 / Revised: 12 January 2023 / Accepted: 20 January 2023 / Published: 24 January 2023
(This article belongs to the Special Issue New Therapeutic and Management Strategies for Childhood Cancers)

Abstract

The purpose of this study was to analyze renal late effects after proton beam therapy (PBT) for pediatric malignant tumors. A retrospective study was performed in 11 patients under 8 years of age who received PBT between 2013 and 2018. The kidney was exposed in irradiation of the primary lesion in all cases. Kidney volume and contour were measured on CT or MRI. Dose volume was calculated with a treatment-planning system. The median follow-up was 24 months (range, 11–57 months). In irradiated kidneys and control contralateral kidneys, the median volume changes were −5.63 (−20.54 to 7.20) and 5.23 (−2.01 to 16.73) mL/year; and the median % volume changes at 1 year were −8.55% (−47.52 to 15.51%) and 9.53% (−2.13 to 38.78%), respectively. The median relative volume change for irradiated kidneys at 1 year was −16.42% (−52.21 to −4.53%) relative to control kidneys. Kidneys irradiated with doses of 10, 20, 30, 40, and 50 GyE had volume reductions of 0.16%, 0.90%, 1.24%, 2.34%, and 8.2% per irradiated volume, respectively. The larger the irradiated volume, the greater the kidney volume was lost. Volume reduction was much greater in patients aged 4–7 years than in those aged 2–3 years. The results suggest that kidneys exposed to PBT in treatment of pediatric malignant tumor show continuous atrophy in follow-up. The degree of atrophy is increased with a higher radiation dose, greater irradiated volume, and older age. However, with growth and maturation, the contralateral kidney becomes progressively larger and is less affected by radiation.
Keywords: pediatric malignant tumor; proton beam therapy; radiation therapy; renal atrophy; late effects pediatric malignant tumor; proton beam therapy; radiation therapy; renal atrophy; late effects

Share and Cite

MDPI and ACS Style

Li, Y.; Mizumoto, M.; Oshiro, Y.; Nitta, H.; Saito, T.; Iizumi, T.; Kawano, C.; Yamaki, Y.; Fukushima, H.; Hosaka, S.; Maruo, K.; Kamizawa, S.; Sakurai, H. A Retrospective Study of Renal Growth Changes after Proton Beam Therapy for Pediatric Malignant Tumor. Curr. Oncol. 2023, 30, 1560-1570. https://doi.org/10.3390/curroncol30020120

AMA Style

Li Y, Mizumoto M, Oshiro Y, Nitta H, Saito T, Iizumi T, Kawano C, Yamaki Y, Fukushima H, Hosaka S, Maruo K, Kamizawa S, Sakurai H. A Retrospective Study of Renal Growth Changes after Proton Beam Therapy for Pediatric Malignant Tumor. Current Oncology. 2023; 30(2):1560-1570. https://doi.org/10.3390/curroncol30020120

Chicago/Turabian Style

Li, Yinuo, Masashi Mizumoto, Yoshiko Oshiro, Hazuki Nitta, Takashi Saito, Takashi Iizumi, Chie Kawano, Yuni Yamaki, Hiroko Fukushima, Sho Hosaka, Kazushi Maruo, Satoshi Kamizawa, and Hideyuki Sakurai. 2023. "A Retrospective Study of Renal Growth Changes after Proton Beam Therapy for Pediatric Malignant Tumor" Current Oncology 30, no. 2: 1560-1570. https://doi.org/10.3390/curroncol30020120

Article Metrics

Back to TopTop