Multiple Biological Mechanisms for the Potential Influence of Phytochemicals on Physical Activity Performance: A Narrative Review
Abstract
:1. Introduction
- Ameliorating post-exercise oxidative stress pathways;
- Protecting joints and tendons;
- Reducing delayed-onset muscle symptoms and muscle damage;
- Improving muscle and tissue oxygenation;
- Improving gut health;
- Helping to restore circadian rhythm, improve sleep, and reduce daytime fatigue;
- Elevating mood and motivation to exercise;
- Reducing viral colds and flu, which disrupt training.
1.1. Oxidative Stress and DNA Damage
1.2. Protection of Joints and Tendons
1.3. Delayed Onset Muscle Soreness (DOMS)
1.4. Improved Nitric Oxide Production and Oxygen Utilisation
1.5. Improving Gut Health
1.6. Helping Restore Circadian Rhythm, Improving Sleep, and Reducing Day Time Fatigue
1.7. Reducing Stress and Elevating Mood and Motivation to Exercise
1.8. Anti-Viral Properties: Avoiding Breaks in Training from Colds and Flu
Polyphenols 1. Flavonoids Flavonols: quercetin, kaempferol (onions, kale, leeks, broccoli, red grapes, tea, apples) Flavones: apigenin, luteolin (celery, herbs, parsley, chamomile, rooibos tea, capsicum pepper) Isoflavones: genistein, daidzein, glycitein (soya, beans, chick peas, alfalfa, peanuts) Flavanones: naringenin, hesperetin (citrus fruit) Anthocyanidins (red grapes, blueberries, cherries, strawberries, blackberries, raspberries, tea) Flavan-3-ols (tannins): catechins, epicatechin, epigallocatechin gallate (tea, chocolate, grapes) Flavanolols: silymarin, silibinin, aromadedrin (milk thistle, red onions) Dihydrochalcones: phloridzin, aspalathin (apples, rooibos tea) 2. Phenolic acids Hydrobenzoic acids: gallic acid, ellagic acid, vanillic acid (rhubarb, grapes, raspberries, blackberries, pomegranate, vanilla, tea) Hydroxycinnamic acids: ferulic acid, P-coumaric acid, caffeic acid, sinapic acid (wheat bran, cinnamon, coffee, kiwi fruit, plums, blueberries) 3. Other non-flavonoid polyphenols Other tannins (cereals, fruits, berries, beans, nuts, wine, cocoa) Curcuminoids: curcumin (turmeric) Stilbenes: cinnamic acid, resveratrol (grapes, wine, blueberries, peanuts, raspberries) Lignans: secoisolariciresinol, enterolactone, sesamin (grains, flaxseed, sesame seeds) |
Terpenoids 1. Carotenoid terpenoids Alpha, beta and gamma carotene (sweet potato, carrots, pumpkin, kale) Lutein (corn, eggs, kale, spinach, red pepper, pumpkin, oranges, rhubarb, plum, mango, papaya) Zeaxanthin (corn, eggs, kale, spinach, red pepper, pumpkin, oranges) Lycopene (tomatoes watermelon, pink grapefruit, guava, papaya) Astaxanthin (salmon, shrimp, krill, crab) 2. Non-carotenoid terpenoids Saponins (chickpeas, soya beans) Limonene (the rind of citrus fruits) Perillyl Alcohol (cherries, caraway seeds, mint) Phytosterols: natural cholesterols, siosterol, stigmasterol, campesterol (vegetable oils, cereal grains, nuts, shoots, seeds, seed oils, whole grains, legumes) Ursolic acid (apples, cranberries, prunes, peppermint, oregano, thyme) Ginkgolide and bilobalide (Ginkgo biloba) |
Thiols Glucosinolates: isothiocyanates (sulforaphane), dithiolthiones (cruciferous vegetables; broccoli, asparagus, Brussel sprouts, cauliflower, horseradish, radish, mustard) Allylic sulfides: allicin and S-allyl cysteine (garlic, leeks, onions) Indoles: Indole-3-carbinol (broccoli, brussel sprouts) |
Other PCs Betaines found in beetroot Chlorophylls found in green leafy vegetables Capsaicin found in chilli Peperine found in black peppers |
2. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- McAuley, A.B.; Baker, J.; Kelly, A.L. How nature and nurture conspire to influence athletic success. In Birth Advantages and Relative Age Effects in Sport; Routledge: London, UK, 2021; pp. 159–183. [Google Scholar]
- Rawson, E.S.; Miles, M.P.; Larson-Meyer, D.E. Dietary Supplements for Health, Adaptation and Recovery in Athletes. Int. J. Sport Nutr. Exerc. Metab. 2018, 28, 188–199. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Schmid, M.J.; Charbonnet, B.; Conzelmann, A.; Zuber, C. More Success with the Optimal Motivational Pattern? A Prospective Longitudinal Study of Young Athletes in Individual Sports. Front. Psychol. 2021, 11, 606272. [Google Scholar] [CrossRef] [PubMed]
- Thomas, R.; Kenfield, S.A.; Jimenez, A. Exercise-induced biochemical changes and their potential influence on cancer: A scientific review. Br. J. Sport. Med. 2017, 51, 640–644. [Google Scholar] [CrossRef] [PubMed]
- Thomas, R.; Kenfield, S.A.; Yanagisawa, Y.; Newton, R. Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes. Br. Med. Bull. 2021, 139, 100–119. [Google Scholar] [CrossRef] [PubMed]
- Batty, M.; Bennett, M.R.; Yu, E. The role of oxidative stress in atherosclerosis. Cells 2022, 11, 3843. [Google Scholar] [CrossRef] [PubMed]
- Buccellato, F.; D’Anca, M.; Fenoglio, C.; Scarpini, E.; Galimberti, D. Role of oxidative damage in alzheimer’s disease and neurodegeneration: From pathogenic mechanisms to biomarker discovery. Antioxidants 2021, 10, 1353. [Google Scholar] [CrossRef]
- Forman, H.J.; Zhang, H. Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy. Nat. Rev. Drug Discov. 2021, 20, 689–709. [Google Scholar] [CrossRef]
- Powers, S.K.; Goldstein, E.; Schrager, M.; Ji, L.L. Exercise Training and Skeletal Muscle Antioxidant Enzymes: An Update. Antioxidants 2023, 12, 39. [Google Scholar] [CrossRef]
- Kojda, G.; Hambrecht, R. Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy? Cardiovasc. Res. 2005, 67, 187–197. [Google Scholar] [CrossRef] [Green Version]
- Poljsak, B. Strategies for reducing or preventing the generation of oxidative stress. Oxid. Med. Cell. Longev. 2011, 2011, 194586. [Google Scholar] [CrossRef] [Green Version]
- Ristow, M.; Zarse, K.; Oberbach, A. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc. Natl. Acad. Sci. USA 2009, 106, 8665–8670. [Google Scholar] [CrossRef]
- Schulz, T.J.; Zarse, K.; Voigt, A.; Urban, N.; Birringer, M.; Ristow, M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007, 6, 280–293. [Google Scholar] [CrossRef] [Green Version]
- Martel, J.; Ojcius, D.M.; Ko, Y.F.; Ke, P.Y.; Wu, C.Y.; Peng, H.H.; Young, J.D. Hormetic effects of phytochemicals on health and longevity. Trends Endocrinol. Metab. 2019, 30, 335–346. [Google Scholar] [CrossRef]
- Thomas, R.; Butler, E.; Macchi, F.; Williams, M. Phytochemicals in cancer prevention and management? Br. J. Med. Pract. 2015, 8, 348–354. [Google Scholar]
- Dimauro, I.; Grazioli, E.; Lisi, V.; Guidotti, F.; Fantini, C.; Antinozzi, C.; Sgrò, P.; Antonioni, A.; Di Luigi, L.; Capranica, L.; et al. Systemic response of antioxidants, heat shock proteins, and inflammatory biomarkers to short-lasting exercise training in healthy male subjects. Oxid. Med. Cell. Longev. 2021, 2021, 1938492. [Google Scholar] [CrossRef]
- Marseglia, L.; Manti, S.; D’Angelo, G.; Nicotera, A.; Parisi, E.; Di Rosa, G.; Gitto, E.; Arrigo, T. Oxidative Stress in Obesity: A Critical Component in Human Diseases. Int. J. Mol. Sci. 2015, 16, 378. [Google Scholar] [CrossRef] [Green Version]
- Magbanua, M.J.; Richman, E.L.; Sosa, E.V.; Jones, L.W.; Simko, J.; Shinohara, K. Physical activity and prostate gene expression in men with low-risk prostate cancer. Cancer Causes Control 2014, 25, 515–523. [Google Scholar] [CrossRef] [Green Version]
- Higgins, M.R.; Izadi, A.; Kaviani, M. Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation. Int. J. Environ. Res. Public Health 2020, 17, 8452. [Google Scholar] [CrossRef]
- Vargas-Mendoza, N.; Morales-González, Á.; Madrigal-Santillán, E.O.; Madrigal-Bujaidar, E.; Álvarez-González, I.; García-Melo, L.F.; Anguiano-Robledo, L.; Fregoso-Aguilar, T.; Morales-Gonzalez, J.A. Antioxidant and adaptative response mediated by Nrf2 during physical exercise. Antioxidants 2019, 8, 196. [Google Scholar] [CrossRef] [Green Version]
- Avery, N.G.; Kaiser, J.L.; Sharman, M.J.; Scheett, T.P.; Barnes, D.M.; Gómez, A.L. Effects of vitamin E supplementation on recovery from repeated bouts of resistance exercise. J. Strength Cond. Res. 2003, 17, 801–809. [Google Scholar]
- McMahon, M.; Itoh, K.; Yamamoto, M. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J. Biol. Chem. 2003, 278, 21592–21600. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Peternelj, T.T.; Coombes, J.S. Antioxidant Supplementation during Exercise Training: Beneficial or Detrimental? Sport. Med. 2011, 41, 1043–1069. [Google Scholar] [CrossRef] [PubMed]
- Lotito, S.B.; Frei, B. Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence or epiphenomenon? Free Radic. Biol. Med. 2006, 41, 1727–1746. [Google Scholar] [CrossRef] [PubMed]
- Miller, E.R.; Pastor-Barriuso, R.; Appel, L.J.; Guallar, E. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann. Intern. Med. 2005, 142, 37–46. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ghazzawi, H.A.; Hussain, M.A.; Raziq, K.M.; Alsendi, K.K.; Alaamer, R.O.; Jaradat, M.; Alobaidi, S.; Al Aqili, R.; Trabelsi, K.; Jahrami, H. Exploring the Relationship between Micronutrients and Athletic Performance: A Comprehensive Scientific Systematic Review of the Literature in Sports Medicine. Sports 2023, 11, 109. [Google Scholar] [CrossRef]
- Myung, S.K.; Kim, Y.; Ju, W.; Choi, H.J.; Bae, W.K. Effects of antioxidant supplements on cancer prevention: Meta-analysis of randomized controlled trials. Ann. Oncol. 2010, 21, 166–179. [Google Scholar] [CrossRef]
- Collins, R.; Armitage, J.; Parish, S.; Sleight, P.; Peto, R. MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet 2002, 360, 23–33. [Google Scholar]
- Mursu, J.; Robien, K.; Harnack, L.J.; Park, K.; Jacobs, D.R., Jr. Dietary supplements and mortality rate in older women: The Iowa women’s health study. Arch. Intern. Med. 2011, 171, 1625–1633. [Google Scholar] [CrossRef]
- Crum, E.M.; Barnes, M.J.; Stannard, S.R. Multiday pomegranate extract supplementation decreases oxygen uptake during submaximal cycling exercise, but co-supplementation with N-acetylcysteine negates the effect. Int. J. Sport Nutr. Exerc. Metab. 2018, 28, 586–592. [Google Scholar] [CrossRef]
- Gomez-Cabrera, M.-C.; Domenech, E.; Romagnoli, M.; Arduini, A.; Borras, C.; Pallardo, F.V.; Sastre, J.; Viña, J. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am. J. Clin. Nutr. 2008, 87, 142–149. [Google Scholar] [CrossRef] [Green Version]
- Thomas, R.; Williams, M.; Sharma, H.; Chaudry, A.; Bellamy, P. A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer-the U.K. NCRN Pomi-T study. Prostate Cancer Prostatic Dis. 2014, 17, 180–186. [Google Scholar] [CrossRef] [Green Version]
- Malaguti, M.; Angeloni, C.; Hrelia, S. Polyphenols in exercise performance and prevention of exercise-induced muscle damage. Oxid. Med. Cell. Longev. 2013, 2013, 825928. [Google Scholar] [CrossRef] [Green Version]
- Zarfeshany, A.; Asgary, S.; Javanmard, S.H. Potent health effects of pomegranate. Adv. Biomed. Res. 2014, 3, 100. [Google Scholar] [CrossRef]
- Srivastava, J.K.; Shankar, E.; Gupta, S. Chamomile: A herbal medicine of the past with bright future. Mol. Med. Rep. 2010, 3, 895–901. [Google Scholar] [CrossRef] [Green Version]
- Huang, W.C.; Chiu, W.C.; Chuang, H.L.; Tang, D.-W.; Lee, Z.-M.; Wei, L. Effect of curcumin supplementation on physiological fatigue and physical performance in mice. Nutrients 2015, 7, 905–921. [Google Scholar] [CrossRef] [Green Version]
- Ammar, A.; Turki, M.; Chtourou, H.; Hammouda, O.; Trabelsi, K.; Kallel, C. Pomegranate Supplementation Accelerates Recovery of Muscle Damage and Soreness and Inflammatory Markers after a Weightlifting Training Session. PLoS ONE 2016, 11, e0160305. [Google Scholar] [CrossRef] [Green Version]
- Gonçalves, A.C.; Gaspar, D.; Flores-Félix, J.D.; Falcão, A.; Alves, G.; Silva, L.R. Effects of Functional Phenolics Dietary Supplementation on Athletes’ Performance and Recovery: A Review. Int. J. Mol. Sci. 2022, 23, 4652. [Google Scholar] [CrossRef]
- Kawabata, S.; Murata, K.; Nakao, K.; Sonoo, M.; Morishita, Y.; Oka, Y.; Kubota, K.; Kuroo-Nakajima, A.; Kita, S.; Nakagaki, S.; et al. Effects of exercise therapy on joint instability in patients with osteoarthritis of the knee: A systematic review. Osteoarthr. Cartil. Open 2020, 2, 100114. [Google Scholar] [CrossRef]
- Firth, J.; Rosenbaum, S.; Stubbs, B.; Gorczynski, P.; Yung, A.R.; Vancampfort, D. Motivating factors and barriers towards exercise in severe mental illness: A systematic review and meta-analysis. Psychol. Med. 2016, 46, 2869–2881. [Google Scholar] [CrossRef] [Green Version]
- Brand, R.; Cheval, B. Theories to Explain Exercise Motivation and Physical Inactivity: Ways of Expanding Our Current Theoretical Perspective. Front. Psychol. 2019, 10, 1147. [Google Scholar] [CrossRef] [Green Version]
- McFarlin, B.K.; Venable, A.S.; Henning, A.L.; Best Sampson, J.N.; Pennel, K.; Vingren, J.L. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin. 2016, 18, 72–78. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Tian, Z.; Zhang, X.; Sun, M. Phytochemicals Mediate Autophagy Against Osteoarthritis by Maintaining Cartilage Homeostasis. Front. Pharmacol. 2021, 12, 795058. [Google Scholar] [CrossRef] [PubMed]
- Alamgeer; Hasan, U.H.; Uttra, A.M.; Qasim, S.; Ikram, J.; Saleem, M.; Niazi, Z.R. Phytochemicals targeting matrix metalloproteinases regulating tissue degradation in inflammation and rheumatoid arthritis. Phytomedicine 2020, 66, 153134. [Google Scholar] [CrossRef] [PubMed]
- Bhattacharya, S.O.; Mandal, S.K.; Akhtar, M.S.; Dastider, D.I.; Sarkar, S.I.; Bose, S.A.; Bose, A.N.; Mandal, S.A.; Kolay, A.R.; Sen, D.J.; et al. Phytochemicals in the treatment of arthritis: Current knowledge. Int. J. Curr. Pharma Res. 2020, 12, 1–6. [Google Scholar] [CrossRef]
- Sirše, M. Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms. Life 2022, 12, 436. [Google Scholar] [CrossRef]
- Chaudhari, R.; Dhole, V.; More, S.; Kushwaha, S.T.; Takarkhede, S. Health Benefits of Herbs and Spices—Review. World J. Pharm. Res. 2021, 10, 1050–1061. [Google Scholar]
- Davis, J.M.; Murphy, E.A.; Carmichael, M.D.; Zielinski, M.R.; Groschwitz, C.M.; Brown, A.S. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 292, 2168–2173. [Google Scholar] [CrossRef] [Green Version]
- Zeng, L.; Yang, T.; Yang, K.; Yu, G.; Li, J.; Xiang, W.; Chen, H. Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial. Front. Immunol. 2022, 13, 891822. [Google Scholar] [CrossRef]
- Nieman, D.C.; Shanely, R.A.; Luo, B.; Dew, D.; Meaney, M.P.; Sha, W. A commercialized dietary supplement alleviates joint pain in community adults: A double-blind, placebo-controlled community trial. Nutr. J. 2013, 12, 154. [Google Scholar] [CrossRef] [Green Version]
- Sabzevar, M.K.; Haghighi, A.; Askari, R. The Effect of Short-term Use of Chamomile Essence on Muscle Soreness in Young Girls after an Exhaustive Exercise. J. Med. Plants 2017, 16, 63–73. [Google Scholar]
- Heiss, R.; Lutter, C.; Freiwald, J.; Hoppe, M.W.; Grim, C.; Poettgen, K.; Forst, R.; Bloch, W.; Hüttel, M.; Hotfiel, T. Advances in delayed-onset muscle soreness (DOMS)–part II: Treatment and prevention. Sportverletz. Sportschaden 2019, 33, 21–29. [Google Scholar] [CrossRef]
- Meamarbashi, A. Herbs and natural supplements in the prevention and treatment of delayed-onset muscle soreness. Avicenna J. Phytomed 2017, 7, 16–26. [Google Scholar]
- Visconti, L.; Forni, C.; Coser, R.; Trucco, M.; Magnano, E.; Capra, G. Comparison of the effectiveness of manual massage, long-wave diathermy, and sham long-wave diathermy for the management of delayed-onset muscle soreness: A randomized controlled trial. Arch. Physiother. 2020, 10, 1. [Google Scholar] [CrossRef]
- Basham, S.A.; Waldman, H.S.; McAllister, M.J. Effect of Curcumin Supplementation on Exercise-Induced Oxidative Stress, Inflammation, Muscle Damage and Muscle Soreness. J. Diet. Suppl. 2019, 17, 401–414. [Google Scholar]
- Sonkodi, B. Delayed onset muscle soreness and critical neural microdamage-derived neuroinflammation. Biomolecules 2022, 12, 1207. [Google Scholar] [CrossRef]
- Hartono, S.; Widodo, A.; Wismanadi, H.; Hikmatyar, G. The effects of roller massage, massage, and ice bath on lactate removal and delayed onset muscle soreness. Sport Mont. 2019, 17, 111–114. [Google Scholar]
- Angelopoulos, P.; Diakoronas, A.; Panagiotopoulos, D.; Tsekoura, M.; Xaplanteri, P.; Koumoundourou, D.; Saki, F.; Billis, E.; Tsepis, E.; Fousekis, K. Cold-Water Immersion and Sports Massage Can Improve Pain Sensation but Not Functionality in Athletes with Delayed Onset Muscle Soreness. Healthcare 2022, 10, 2449. [Google Scholar] [CrossRef]
- Thanawala, S.; Shah, R.; Karlapudi, V.; Desomayanandam, P.; Bhuvanendran, A. Efficacy and Safety of TurmXTRA® 60N in Delayed Onset Muscle Soreness in Healthy, Recreationally Active Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial. Evid. Based Complement. Altern. Med. 2022, 2022, 9110414. [Google Scholar] [CrossRef]
- Chilelli, N.C.; Ragazzi, E.; Valentini, R.; Cosma, C.; Ferraresso, S.; Lapolla, A. Curcumin and Boswellia serrata modulate the glyco-oxidative status and lipo-oxidation in master athletes. Nutrients 2016, 8, 745. [Google Scholar] [CrossRef]
- Trombold, J.R.; Reinfeld, A.S.; Casler, J.R.; Coyle, E.F. The effect of pomegranate juice supplementation on strength and soreness after eccentric exercise. J. Strength Cond. Res. 2011, 25, 1782–1788. [Google Scholar] [CrossRef]
- Ammar, A.; Turki, M.; Hammouda, O.; Chtourou, H.; Trabelsi, K.; Bouaziz, M. Effects of pomegranate juice supplementation on oxidative stress biomarkers following weightlifting exercise. Nutrients 2017, 29, 819. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Levers, K.; Dalton, R.; Galvan, E.; Goodenough, C.; O’Connor, A.; Simbo, S. Effects of powdered Montmorency tart cherry supplementation on an acute bout of intense lower body strength exercise in resistance trained males. J. Int. Soc. Sport. Nutr. 2015, 12, 41. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Braakhuis, A.J.; Somerville, V.X.; Hurst, R.D. The effect of New Zealand blackcurrant on sport performance and related biomarkers: A systematic review and meta-analysis. J. Int. Soc. Sport. Nutr. 2020, 17, 25. [Google Scholar] [CrossRef] [PubMed]
- Gao, R.; Chilibeck, P.D. Effect of tart cherry concentrate on endurance exercise performance: A meta-analysis. J. Am. Coll. Nutr. 2020, 39, 657–664. [Google Scholar] [CrossRef]
- Song, P.; Wu, L.; Guan, W. Dietary Nitrates, Nitrites and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-Analysis. Nutrients 2015, 7, 9872–9895. [Google Scholar] [CrossRef] [Green Version]
- Bond, H.; Morton, L.; Braakhuis, A.J. Nitrate rich foods: Dietary nitrate supplementation improves rowing performance in well-trained rowers. Int. J. Sport Nutr. Exerc. Metab. 2012, 22, 251–256. [Google Scholar] [CrossRef]
- Jonvik, K.L.; Nyakayiru, J.; van Dijk, J.-W.; Wardenaar, F.C.; van Loon, L.J.C.; Verdijk, L.B. Habitual Dietary Nitrate Intake in Highly Trained Athletes. Int. J. Sport Nutr. Exerc. Metab. 2017, 27, 148–155. [Google Scholar] [CrossRef] [Green Version]
- Lundberg, J.O.; Carlström, M.; Larsen, F.J.; Weitzberg, E. Roles of dietary inorganic nitrate in cardiovascular health and disease. Cardiovasc. Res. 2011, 89, 525–532. [Google Scholar] [CrossRef]
- Dias, C.; Lourenço, C.F.; Laranjinha, J.; Ledo, A. Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite. Free Radic. Biol. Med. 2022, 193, 779–786. [Google Scholar] [CrossRef]
- Nebl, J.; Drabert, K.; Haufe, S.; Wasserfurth, P.; Eigendorf, J.; Tegtbur, U.; Hahn, A.; Tsikas, D. Exercise-induced oxidative stress, nitric oxide and plasma amino acid profile in recreational runners with vegetarian and non-vegetarian dietary patterns. Nutrients 2019, 11, 1875. [Google Scholar] [CrossRef] [Green Version]
- Bonnar, D.; Bartel, K.; Kakoschke, N.; Lang, C. Sleep Interventions Designed to Improve Athletic Performance and Recovery: A Systematic Review of Current Approaches. Sport. Med. 2018, 48, 683–703. [Google Scholar] [CrossRef]
- D’Angelo, S. Polyphenols and athletic performance: A review on human data. In Plant Physiological Aspects of Phenolic Compounds; IntechOpen: London, UK, 2019. [Google Scholar] [CrossRef] [Green Version]
- Myburgh, K.H. Polyphenol supplementation: Benefits for exercise performance or oxidative stress? Sport. Med. 2014, 44 (Suppl. S1), S57–S70. [Google Scholar] [CrossRef]
- Cermak, N.M.; Gibala, M.J.; van Loon, L.J.C. Nitrate supplementation’s improvement of 10-km time-trial performance in trained cyclists. Int. J. Sport. Nutr. Exerc. 2012, 22, 64–71. [Google Scholar] [CrossRef]
- Jones, A. Dietary Nitrate Supplementation and Exercise Performance. Sport. Med. 2014, 44 (Suppl. S1), 35–45. [Google Scholar] [CrossRef] [Green Version]
- Ormsbee, M.J.; Lox, J.; Arciero, P.J. Beetroot juice and exercise performance. J. Int. Soc. Sport. Nutr. 2013, 5, 27–35. [Google Scholar] [CrossRef] [Green Version]
- Jówko, E.; Długołęcka, B.; Makaruk, B.; Cieśliński, I. The effect of green tea extract supplementation on exercise-induced oxidative stress parameters in male sprinters. Eur. J. Nutr. 2015, 54, 783–791. [Google Scholar] [CrossRef] [Green Version]
- Machado, Á.S.; da Silva, W.; Souza, M.A.; Carpes, F.P. Green tea extract preserves neuromuscular activation and muscle damage markers in athletes under cumulative fatigue. Front. Physiol. 2018, 17, 1137. [Google Scholar]
- Ota, N.; Soga, S.; Shimotoyodome, A. Daily consumption of tea catechins improves aerobic capacity in healthy male adults: A randomized, double-blind, placebo-controlled, crossover trial. Biosci. Biotechnol. Biochem. 2016, 80, 2412–2417. [Google Scholar] [CrossRef] [Green Version]
- Overdevest, E.; Wouters, J.A.; Wolfs, K.H.M.; van Leeuwen, J.J.M.; Possemiers, S. Citrus Flavonoid Supplementation Improves Exercise Performance in Trained Athletes. J. Sport. Sci. Med. 2018, 17, 24–30. [Google Scholar]
- Imperatrice, M.; Cuijpers, I.; Troost, F.J.; Sthijns, M.M. Hesperidin Functions as an Ergogenic Aid by Increasing Endothelial Function and Decreasing Exercise-Induced Oxidative Stress and Inflammation, Thereby Contributing to Improved Exercise Performance. Nutrients 2022, 14, 2955. [Google Scholar] [CrossRef]
- Lee, M.-C.; Ho, C.-S.; Hsu, Y.-J.; Huang, C.-C. Live and Heat-Killed Probiotic Lactobacillus paracasei PS23 Accelerated the Improvement and Recovery of Strength and Damage Biomarkers after Exercise-Induced Muscle Damage. Nutrients 2022, 14, 4563. [Google Scholar] [CrossRef] [PubMed]
- De Vos, W.M.; Tilg, H.; Van Hul, M.; Cani, P.D. Gut microbiome and health: Mechanistic insights. Gut 2022, 71, 1020–1032. [Google Scholar] [CrossRef] [PubMed]
- Ale, E.C.; Binetti, A.G. Role of Probiotics, Prebiotics, and Synbiotics in the Elderly: Insights into Their Applications. Front. Microbiol. 2021, 12, 631254. [Google Scholar] [CrossRef] [PubMed]
- Powanda, M.C.; Whitehouse, M.W.; Rainsford, K.D. Celery Seed and Related Extracts with Antiarthritic, Antiulcer and Antimicrobial Activities. Prog. Drug. Res. 2015, 70, 133–153. [Google Scholar] [PubMed]
- Alves-Santos, A.M.; de Araújo Sugizaki, C.S.; Lima, G.C.; Veloso Naves, M.M. Prebiotic effect of dietary polyphenols: A systematic review. J. Funct. Foods 2020, 74, 104169. [Google Scholar] [CrossRef]
- Al Azzaz, J.; Al Tarraf, A.; Heumann, A.; Da Silva Barreira, D.; Laurent, J.; Assifaoui, A. Resveratrol Favors Adhesion and Biofilm Formation of Lacticaseibacillus paracasei subsp. paracasei Strain ATCC334. Int. J. Mol. Sci. 2020, 21, 5423. [Google Scholar] [CrossRef]
- Arcanjo, N.O.; Andrade, M.J.; Padilla, P.; Rodríguez, A.; Madruga, M.S.; Estévez, M. Resveratrol protects Lactobacillus reuteri against H2O2-induced oxidative stress and stimulates antioxidant defenses through upregulation of the dhaT gene. Free Radic. Biol. Med. 2019, 1, 38–45. [Google Scholar] [CrossRef]
- Bolte, L.A.; Vich Vila, A.; Imhann, F.; Collij, V.; Gacesa, R.; Peters, V. Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome. Gut 2021, 70, 1287–1298. [Google Scholar] [CrossRef]
- Zhang, Y.J.; Li, S.; Gan, R.Y.; Zhou, T.; Xu, D.P.; Li, H.B. Impacts of gut bacteria on human health and diseases. Int. J. Mol. Sci. 2015, 16, 7493–7519. [Google Scholar] [CrossRef]
- Jäger, R.; Mohr, A.E.; Carpenter, K.C.; Kerksick, C.M.; Kreider, R.B.; Campbell, B.I. International Society of Sports Nutrition Position Stand: Probiotics. J. Int. Soc. Sport. Nutr. 2019, 16, 62. [Google Scholar] [CrossRef] [Green Version]
- Makin, S. Do microbes affect athletic performance? Nature 2021, 592, S17–S19. [Google Scholar] [CrossRef]
- Estaki, M.; Pither, J.; Baumeister, P.; Little, J.P.; Gill, S.K.; Ghosh, S. Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions. Microbiome 2016, 4, 42. [Google Scholar] [CrossRef] [Green Version]
- Łagowska, K.; Bajerska, J. Probiotic and prebiotic supplementation and Respiratory Infection and Immune Function in Athletes: Systematic Review and Meta-Analysis of Randomized Controlled Trials. J. Athl. Train. 2021, 56, 1213–1223. [Google Scholar] [CrossRef]
- Morishima, S.; Aoi, W.; Kawamura, A.; Kawase, T.; Takagi, T.; Naito, Y.; Tsukahara, T.; Inoue, R. Intensive, prolonged exercise seemingly causes gut dysbiosis in female endurance runners. J. Clin. Biochem. Nutr. 2021, 68, 253–258. [Google Scholar] [CrossRef]
- Jones, M.L. Oral lactobacillus probiotics increases circulating vitamin D: A randomized controlled trial. J. Clin. Endocrinol. Metab. 2013, 98, 2944–2951. [Google Scholar] [CrossRef] [Green Version]
- Luyster, F.S.; Strollo, P.J., Jr.; Zee, P.C.; Walsh, J.K. Sleep: A health imperative. Sleep 2012, 35, 727–734. [Google Scholar] [CrossRef]
- Tips for a Better Night’s Sleep. Available online: https://www.keep-healthy.com/sleep/ (accessed on 27 February 2023).
- Olarescu, N.C.; Gunawardane, K.; Hansen, T.K.; Møller, N.; Jørgensen, J.O. Normal physiology of growth hormone in adults. In Endotext [Internet]; MDText: South Dartmouth, MA, USA, 2019. [Google Scholar]
- Kline, C.E. The bidirectional relationship between exercise and sleep: Implications for exercise adherence and sleep improvement. Am. J. Lifestyle Med. 2014, 8, 375–379. [Google Scholar] [CrossRef] [Green Version]
- Huang, J.Q.; Lu, M.; Ho, C.T. Health benefits of dietary chronobiotics: Beyond resynchronizing internal clocks. Food Funct. 2021, 12, 6136–6156. [Google Scholar] [CrossRef]
- Noruzi, Z.; Shiraseb, F.; Mirzababaei, A.; Mirzaei, K. Association of the dietary phytochemical index with circadian rhythm and mental health in overweight and obese women: A cross-sectional study. Clin. Nutr. ESPEN 2022, 48, 393–400. [Google Scholar] [CrossRef]
- Qiaoyu, S.; Ho, C.-T.; Zhang, X.; Liu, Y.; Zhanga, R.; Wua, Z. Strategies for circadian rhythm disturbances and related psychiatric disorders: A new cue based on plant polysaccharides and intestinal microbiota. Food Funct. 2022, 13, 1048. [Google Scholar]
- Xu, T.; Lu, B. The effects of PCs on circadian rhythm and related diseases. Crit. Rev. Food Sci. Nutr. 2019, 59, 882–892. [Google Scholar] [CrossRef] [PubMed]
- Ziemann, J.; Lendeckel, A.; Müller, S.; Horneber, M.; Ritter, C.A. Herb-drug interactions: A novel algorithm-assisted information system for pharmacokinetic drug interactions with herbal supplements in cancer treatment. Eur. J. Clin. Pharmacol. 2019, 75, 1237–1248. [Google Scholar] [CrossRef] [PubMed]
- Amsterdam, J.; Li, Y.; Soeller, I.; Rockwell, K.; Mao, J.; Shults, J. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J. Clin. Psychopharmacol. 2009, 29, 378. [Google Scholar] [CrossRef] [PubMed]
- Amsterdam, J.; Shults, J.; Soeller, I.; Mao, J.J.; Rockwell, K.; Newberg, A.B. Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: An exploratory study. Altern. Ther. Health Med. 2012, 18, 44–49. [Google Scholar]
- Mao, J.J.; Li, Q.S.; Soeller, I.; Rockwell, K.; Xie, S.X.; Amsterdam, J.D. Long-Term Chamomile Therapy of Generalized Anxiety Disorder: A Study Protocol for a Randomized, Double-Blind, Placebo- Controlled Trial. J. Clin. Trials 2014, 4, 188. [Google Scholar] [CrossRef] [Green Version]
- Abdullahzadeh, M.; Matourypour, P.; Naji, S.A. Investigation effect of oral Matricaria chamomilla on sleep quality in elderly people in Isfahan: A randomized control trial. J. Educ. Health Promot. 2017, 5, 53. [Google Scholar]
- De Oliveira, M.R.; Chenet, A.L.; Duarte, A.R.; Scaini, G.; Quevedo, J. Molecular Mechanisms Underlying the Anti-depressant Effects of Resveratrol: A Review. Mol. Neurobiol. 2018, 55, 4543–4559. [Google Scholar] [CrossRef]
- Yu, Y.; Wang, J.; Huang, X. The anti-depressant effects of a novel PDE4 inhibitor derived from resveratrol. Pharm. Biol. 2021, 59, 418–423. [Google Scholar] [CrossRef]
- Philippot, A.; Dubois, V.; Lambrechts, K.; Grogna, D.; Robert, A.; Jonckheer, U.; Chakib, W.; Beine, A.; Bleyenheuft, Y.; De Volder, A.G. Impact of physical exercise on depression and anxiety in adolescent inpatients: A randomized controlled trial. J. Affect. Disord. 2022, 301, 145–153. [Google Scholar] [CrossRef]
- Teixeira, P.J.; Carraça, E.V.; Markland, D.; Silva, M.N.; Ryan, R.M. Exercise, physical activity and self-determination theory: A systematic review. Int. J. Behav. Nutr. Phys. Act. 2012, 9, 78. [Google Scholar] [CrossRef] [Green Version]
- Fraser, S.J.; Chapman, J.J.; Brown, W.J.; Whiteford, H.A.; Burton, N.W. Physical activity attitudes and preferences among inpatient adults with mental illness. Int. J. Ment. Health Nurs. 2015, 24, 413–420. [Google Scholar] [CrossRef]
- Hieu, T.; Dibas, M.; Dila, K.A.S.; Sherif, N.A.; Hashmi, M.U.; Mahmoud, M. Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia and sleep quality: A systematic review and meta-analysis of randomized trials and quasi-randomized trials. Phytother. Res. 2019, 33, 1604–1615. [Google Scholar] [CrossRef]
- Pinto, S.A.; Bohland, E.; Coelho Cde, P.; Morgulis, M.S.; Bonamin, L.V. An animal model for the study of Chamomilla in stress and depression: Pilot study. Homeopathy 2008, 97, 141–144. [Google Scholar] [CrossRef]
- Irandoust, E.; Taheri, K.; Ezdini, M.; Ezdini, E. The effect of four weeks of chamomile extract consumption and endurance training on the anxiety level of young male karate players before the competition. In Proceedings of the 1st International Congress on Sports Sciences & Interdisciplinary Research, Teheran, Iran, 11–12 November 2021. [Google Scholar]
- Grande, A.J.; Keogh, J.; Silva, V.; Scott, A.M. Exercise versus no exercise for the occurrence, severity, and duration of acute respiratory infections. Cochrane Database Syst. Rev. 2020, 103, 144–145. [Google Scholar] [CrossRef] [Green Version]
- Jung, M.H.; Yi, S.W.; An, S.J.; Youn, K.H.; Yi, J.J.; Han, S.; Ihm, S.H.; Jung, H.O.; Youn, H.J.; Ryu, K.H. Association of physical activity and lower respiratory tract infection outcomes in patients with cardiovascular disease. J. Am. Heart Assoc. 2022, 11, e023775. [Google Scholar] [CrossRef]
- Ałązka-Franta, A.; Jura-Szołtys, E.; Smółka, W.; Gawlik, R. Upper Respiratory Tract Diseases in Athletes in Different Sports Disciplines. J. Hum. Kinet. 2016, 53, 99–106. [Google Scholar] [CrossRef] [Green Version]
- Filardo, S.; Di Pietro, M.; Mastromarino, P.; Sessa, R. Therapeutic potential of resveratrol against emerging respiratory viral infections. Pharmacol. Ther. 2020, 214, 107613. [Google Scholar] [CrossRef]
- Khare, P.; Sahu, U.; Pandey, S.C.; Samant, M. Current approaches for target-specific drug discovery using natural compounds against SARS-CoV-2 infection. Virus Res. 2020, 290, 198169. [Google Scholar] [CrossRef]
- Alexova, R.; Alexandrova, S.; Dragomanova, S.; Kalfin, R.; Solak, A.; Mehan, S.; Petralia, M.C.; Fagone, P.; Mangano, K.; Nicoletti, F.; et al. Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L. Molecules 2023, 28, 3772. [Google Scholar] [CrossRef]
- Tito, A.; Colantuono, A.; Pirone, L.; Pedone, E.; Intartaglia, D.; Giamundo, G. Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor: A Promising Source of Novel Antiviral Drugs. Front. Chem. 2021, 28, 81–87. [Google Scholar] [CrossRef]
- Biancatelli, R.M.L.C.; Berrill, M.; Catravas, J.D.; Marik, P.E. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Front. Immunol. 2020, 11, 145–151. [Google Scholar] [CrossRef] [PubMed]
- Jennings, M.R.; Parks, J.R. Curcumin as an Antiviral Agent. Viruses 2020, 12, 1242–1262. [Google Scholar] [CrossRef] [PubMed]
- Thomas, R.; Williams, M.; Aldous, J.; Yanagisawa, Y.; Kumar, R.; Forsyth, R. A Randomised, Double-Blind, Placebo-Controlled Trial Evaluating Concentrated Phytochemical-Rich Nutritional Capsule in Addition to a Probiotic Capsule on Clinical Outcomes among Individuals with COVID-19—The UK Phyto-V Study. COVID 2022, 2, 433–449. [Google Scholar] [CrossRef]
- Thomas, R.; Aldous, J.; Forsyth, R.; Chater, A.; Williams, M. The Influence of a blend of Probiotic Lactobacillus and Prebiotic Inulin on the Duration and Severity of Symptoms among Individuals with COVID-19. Infect. Dis. Diag Treat. 2021, 5, 182. [Google Scholar] [CrossRef]
- Davis, N.; Bateman, L.; Thomas, R. Exercise and lifestyle after cancer—Evidence review. Br. J. Cancer 2011, 105, 52–73. [Google Scholar]
- Thomas, R.; Holm, M.; Williams, M.; Bellamy, P.; Jervoise, A.; Maher, J. Lifestyle factors correlate with the risk of late pelvic symptoms after prostatic radiotherapy. Clin. Oncol. (R. Coll. Radiol.) 2013, 25, 246–251. [Google Scholar] [CrossRef]
- Agarwal, A.; Shen, H.; Agarwal, S.; Rao, A. Lycopene Content of Tomato Products: It’s Stability, Bioavailability and In Vivo Antioxidant Properties. J. Med. Food 2001, 4, 9–15. [Google Scholar] [CrossRef]
- Rickards, L.; Lynn, A.; Harrop, D.; Barker, M.E.; Russell, M.; Ranchordas, M.K. Effect of Polyphenol-Rich Foods, Juices, and Concentrates on Recovery from Exercise Induced Muscle Damage: A Systematic Review and Meta-Analysis. Nutrients 2021, 13, 2988. [Google Scholar] [CrossRef]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Thomas, R.; Williams, M.; Aldous, J.; Wyld, K. Multiple Biological Mechanisms for the Potential Influence of Phytochemicals on Physical Activity Performance: A Narrative Review. Nutraceuticals 2023, 3, 353-365. https://doi.org/10.3390/nutraceuticals3030027
Thomas R, Williams M, Aldous J, Wyld K. Multiple Biological Mechanisms for the Potential Influence of Phytochemicals on Physical Activity Performance: A Narrative Review. Nutraceuticals. 2023; 3(3):353-365. https://doi.org/10.3390/nutraceuticals3030027
Chicago/Turabian StyleThomas, Robert, Madeleine Williams, Jeffrey Aldous, and Kevin Wyld. 2023. "Multiple Biological Mechanisms for the Potential Influence of Phytochemicals on Physical Activity Performance: A Narrative Review" Nutraceuticals 3, no. 3: 353-365. https://doi.org/10.3390/nutraceuticals3030027