Outcome and Subsequent Pregnancy after Fertility-Sparing Surgery of Early-Stage Cervical Cancers

Lee, Chia-Yi; Chen, Yu-Li; Chiang, Ying-Cheng; Cheng, Ching-Yu; Lai, Yen-Ling; Tai, Yi-Jou; Hsu, Heng-Cheng; Hwa, Hsiao-Lin; Cheng, Wen-Fang

doi:10.3390/ijerph17197103

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Outcome and Subsequent Pregnancy after Fertility-Sparing Surgery of Early-Stage Cervical Cancers

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Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 100, Taiwan

Department of Obstetrics and Gynecology, National Taiwan University Hospital, Yun-Lin Branch, Douliou City 640, Yunlin County, Taiwan

Department of Obstetrics and Gynecology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu City 300, Taiwan

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Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan

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Department and Graduate Institute of Forensic Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan

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Department of Medical Genetics, National Taiwan University Hospital, Taipei 100, Taiwan

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Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan

Author to whom correspondence should be addressed.

Int. J. Environ. Res. Public Health 2020, 17(19), 7103; https://doi.org/10.3390/ijerph17197103

Received: 15 August 2020 / Revised: 17 September 2020 / Accepted: 25 September 2020 / Published: 28 September 2020

(This article belongs to the Special Issue Gynecological Cancer)

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Abstract

We aimed to investigate the outcomes and subsequent pregnancies of early-stage cervical cancer patients who received conservative fertility-sparing surgery. Women with early-stage cervical cancer who underwent conservative or fertility-sparing surgery in a tertiary medical center were reviewed from 2004 to 2017. Each patient’s clinicopathologic characteristics, adjuvant therapy, subsequent pregnancy, and outcome were recorded. There were 32 women recruited, including 12 stage IA1 patients and 20 stage IB1 patients. Twenty-two patients received conization/LEEP and the other 10 patients received radical trachelectomy. Two patients did not complete the definite treatment after fertility-sparing surgery. There were 11 women who had subsequent pregnancies and nine had at least one live birth. The live birth rate was 73.3% (11/15). We conclude that patients with early-stage cervical cancer who undergo fertility-sparing surgery can have a successful pregnancy and delivery. However, patients must receive a detailed consultation before surgery and undergo definitive treatment, if indicated, and regular postoperative surveillance. View Full-Text

Keywords: cervical cancer; fertility-sparing surgery; conization; radical trachelectomy; pregnancy

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Lee, C.-Y.; Chen, Y.-L.; Chiang, Y.-C.; Cheng, C.-Y.; Lai, Y.-L.; Tai, Y.-J.; Hsu, H.-C.; Hwa, H.-L.; Cheng, W.-F. Outcome and Subsequent Pregnancy after Fertility-Sparing Surgery of Early-Stage Cervical Cancers. Int. J. Environ. Res. Public Health 2020, 17, 7103. https://doi.org/10.3390/ijerph17197103

AMA Style

Lee C-Y, Chen Y-L, Chiang Y-C, Cheng C-Y, Lai Y-L, Tai Y-J, Hsu H-C, Hwa H-L, Cheng W-F. Outcome and Subsequent Pregnancy after Fertility-Sparing Surgery of Early-Stage Cervical Cancers. International Journal of Environmental Research and Public Health. 2020; 17(19):7103. https://doi.org/10.3390/ijerph17197103

Chicago/Turabian Style

Lee, Chia-Yi, Yu-Li Chen, Ying-Cheng Chiang, Ching-Yu Cheng, Yen-Ling Lai, Yi-Jou Tai, Heng-Cheng Hsu, Hsiao-Lin Hwa, and Wen-Fang Cheng. 2020. "Outcome and Subsequent Pregnancy after Fertility-Sparing Surgery of Early-Stage Cervical Cancers" International Journal of Environmental Research and Public Health 17, no. 19: 7103. https://doi.org/10.3390/ijerph17197103

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