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Open AccessArticle

Enhancement of Contact Lens Disinfection by Combining Disinfectant with Visible Light Irradiation

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Institute of Medical Engineering and Mechatronics, Ulm University of Applied Sciences, Albert-Einstein-Allee 55, 89081 Ulm, Germany
2
Institute of Medical Microbiology and Hygiene, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(17), 6422; https://doi.org/10.3390/ijerph17176422
Received: 21 July 2020 / Revised: 28 August 2020 / Accepted: 29 August 2020 / Published: 3 September 2020
Multiple use contact lenses have to be disinfected overnight to reduce the risk of infections. However, several studies demonstrated that not only microorganisms are affected by the disinfectants, but also ocular epithelial cells, which come into contact via residuals at reinsertion of the lens. Visible light has been demonstrated to achieve an inactivation effect on several bacterial and fungal species. Combinations with other disinfection methods often showed better results compared to separately applied methods. We therefore investigated contact lens disinfection solutions combined with 405 nm irradiation, with the intention to reduce the disinfectant concentration of ReNu Multiplus, OptiFree Express or AOSept while maintaining adequate disinfection results due to combination benefits. Pseudomonads, staphylococci and E. coli were studied with disk diffusion assay, colony forming unit (cfu) determination and growth delay. A log reduction of 4.49 was achieved for P. fluorescens in 2 h for 40% ReNu Multiplus combined with an irradiation intensity of 20 mW/cm2 at 405 nm. For AOSept the combination effect was so strong that 5% of AOSept in combination with light exhibited the same result as 100% AOSept alone. Combination of disinfectants with visible violet light is therefore considered a promising approach, as a reduction of potentially toxic ingredients can be achieved. View Full-Text
Keywords: photoinactivation; 405 nm; visible light; synergy; contact lens disinfection solution; multipurpose solution; pseudomonas photoinactivation; 405 nm; visible light; synergy; contact lens disinfection solution; multipurpose solution; pseudomonas
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MDPI and ACS Style

Hoenes, K.; Spellerberg, B.; Hessling, M. Enhancement of Contact Lens Disinfection by Combining Disinfectant with Visible Light Irradiation. Int. J. Environ. Res. Public Health 2020, 17, 6422.

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