Skeletal Muscle Dysfunction and Exercise Intolerance in Children Treated with Haematopoietic Stem Cell Transplant—A Pilot Feasibility Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Participants
2.2. Descriptive Characteristics and Exercise Tolerance
2.3. Systemic Aerobic Capacity
2.4. Magnetic Resonance Imaging and Spectroscopy
2.5. MR Data Analysis
2.6. Statistical Analyses
3. Results
3.1. Descriptive Characteristics
3.2. Aerobic Exercise Capacity and Habitual Daily Physical Activity
3.3. Magnetic Resonance Spectroscopy
4. Discussion
5. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
References
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HSCT N = 5 | HC N = 5 | p-value | |
---|---|---|---|
Age (years) | 11 ± 1.2 | 12.8 ± 2.4 | 0.172 |
Weight (kg) | 40.4 ± 9.0 | 45.5 ± 15.6 | 0.541 |
Body mass index (kg/m2) | 19.2 ± 3.8 | 18.3 ± 4.8 | 0.749 |
Total body fat tissue (%) | 29.1 ± 8.5 | 23.7 ± 7.1 | 0.348 |
Total body lean mass (kg) | 28.3 ± 5.5 | 35.7 ± 11.0 | 0.226 |
Time post HSCT (months) | 15.8 ± 5.3 | N/A | N/A |
HSCT N = 5 | HC N = 5 | p-value | |
---|---|---|---|
VO2 peak (mL kg−1 min−1) | 27.8 ± 3.4 | 40.3 ± 8.1 | 0.015 * |
Avg weekday total activity (hours/day) | 5.3 ± 1.8 | 6.6 ± 3.3 | 0.476 |
Avg weekday total inactivity (hours/day) | 18.7 ± 1.8 | 17.4 ± 3.3 | 0.484 |
Avg weekend total activity (hours/day) | 6.0 ± 1.4 | 9.3 ± 1.4 | 0.006 * |
Avg weekend total inactivity (hours/day) | 18 ± 1.4 | 14.7 ± 1.4 | 0.006 * |
HSCT N = 5 | HC N = 5 | p-value | |
---|---|---|---|
Power achieved 30 s (watts) | 10.25 ± 2.63 | 13.67 ± 4.04 | 0.229 |
% of predicted power | 85% | 103% | |
Power achieved 60 s (watts) | 8.63 ± 2.98 | 12.67 ± 3.06 | 0.139 |
% of predicted power | 78% | 105% | |
Power achieved 5 × 30 s (watts) | 6.20 ± 1.30 | 9.38 ± 1.38 | 0.009 |
% of predicted power | 64% | 90% |
31P-MRS Measurement | HSCT N = 5 | HC N = 5 | |
---|---|---|---|
Mean Pi (mM) | rest | 2.05 ± 0.32 | 2.02 ± 0.25 |
Mean PCr (mM) | rest | 19.0 ± 1.33 | 18.55 ± 0.75 |
pH dpH | rest 30 s 60 s | 6.87 ± 0.12 0.18 ± 0.05 0.27 ± 0.16 | 6.79 ± 0.21 0.14 ± 0.18 0.15 ± 0.17 |
Pi:PCr (ratio) | rest 30 s 60 s 5 × 30 s | 0.108 ± 0.013 1.11 ± 0.62 1.99 ± 1.15 1.42 ± 1.03 | 0.108 ± 0.013 1.33 ± 0.814 1.60 ± 0.33 2.18 ± 2.58 |
PCr time constant (s) | 30 s 60 s 5 × 30 s | 25.86 ± 10.3 29.69 ± 9.38 24.91 ± 9.51 | 29.88 ± 13.7 27.67 ± 18.8 28.25 ± 14.3 |
ATP production rate (mM/s) High energy phospagen | 30 s 60 s 5 × 30 s | 0.258 ± 0.100 0.173 ± 0.032 0.316 ± 0.128 | 0.284 ± 0.105 0.168 ± 0.026 0.306 ± 0.117 |
ATP production rate (mM/s) Anaerobic glycolysis | 30 s 60 s 5 × 30 s | 0.390 ± 0.078 0.343 ± 0.167 0.552 ± 0.361 | 0.286 ± 0.520 0.205 ± 0.164 0.416 ± 0.676 |
ATP production rate (mM/s) Oxidative phosphorylation | 30 s 60 s 5 × 30 s | 0.264 ± 0.131 0.275 ± 0.056 0.200 ± 0.068 | 0.246 ± 0.045 0.338 ± 0.068 0.162 ± 0.072 |
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West, S.L.; White, G.; Caterini, J.E.; Rayner, T.; Schechter, T.; Nathan, P.C.; Wells, G.D. Skeletal Muscle Dysfunction and Exercise Intolerance in Children Treated with Haematopoietic Stem Cell Transplant—A Pilot Feasibility Study. Int. J. Environ. Res. Public Health 2019, 16, 1608. https://doi.org/10.3390/ijerph16091608
West SL, White G, Caterini JE, Rayner T, Schechter T, Nathan PC, Wells GD. Skeletal Muscle Dysfunction and Exercise Intolerance in Children Treated with Haematopoietic Stem Cell Transplant—A Pilot Feasibility Study. International Journal of Environmental Research and Public Health. 2019; 16(9):1608. https://doi.org/10.3390/ijerph16091608
Chicago/Turabian StyleWest, Sarah L., Gillian White, Jessica E. Caterini, Tammy Rayner, Tal Schechter, Paul C. Nathan, and Greg D. Wells. 2019. "Skeletal Muscle Dysfunction and Exercise Intolerance in Children Treated with Haematopoietic Stem Cell Transplant—A Pilot Feasibility Study" International Journal of Environmental Research and Public Health 16, no. 9: 1608. https://doi.org/10.3390/ijerph16091608