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Marine Drugs
Volume 21
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10.3390/md21010039
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Article

N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis

by
Hong-Yu Zou
1,
Hui-Juan Zhang
1,
Ying-Cai Zhao
1,
Xiao-Yue Li
1,
Yu-Ming Wang
1,2,
Tian-Tian Zhang
1,* and
Chang-Hu Xue
1,2,*
1
College of Food Science and Engineering, Ocean University of China, No.1299 Sansha Road, Qingdao 266404, China
2
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2023, 21(1), 39; https://doi.org/10.3390/md21010039
Submission received: 30 November 2022 / Revised: 22 December 2022 / Accepted: 28 December 2022 / Published: 1 January 2023
(This article belongs to the Special Issue Marine Fish Oils as Functional Foods)
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Abstract

It has been reported that dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) exert therapeutic potential for the preservation of functional β-cell mass. However, the effect of dietary n-3 PUFA deficiency on pancreatic injury and whether the supplementation of n-3 PUFA could prevent the development of pancreatic injury are still not clear. In the present study, an n-3 PUFA deficiency mouse model was established by feeding them with n-3 PUFA deficiency diets for 30 days. Results showed that n-3 PUFA deficiency aggravated streptozotocin (STZ)-induced pancreas injury by reducing the insulin level by 18.21% and the HOMA β-cell indices by 31.13% and the area of islet by 52.58% compared with the STZ group. Moreover, pre-intervention with DHA and EPA for 15 days could alleviate STZ-induced pancreas damage by increasing the insulin level by 55.26% and 44.33%, the HOMA β-cell indices by 118.81% and 157.26% and reversed the area of islet by 196.75% and 205.57% compared to the n-3 Def group, and the effects were significant compared to γ-linolenic acid (GLA) and alpha-linolenic acid (ALA) treatment. The possible underlying mechanisms indicated that EPA and DHA significantly reduced the ration of n-6 PUFA to n-3 PUFA and then inhibited oxidative stress, inflammation and islet β-cell apoptosis levels in pancreas tissue. The results might provide insights into the prevention and alleviation of pancreas injury by dietary intervention with PUFAs and provide a theoretical basis for their application in functional foods.
Keywords: streptozotocin; polyunsaturated fatty acid; pancreas injury; oxidative stress; inflammation; apoptosis; mouse streptozotocin; polyunsaturated fatty acid; pancreas injury; oxidative stress; inflammation; apoptosis; mouse

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MDPI and ACS Style

Zou, H.-Y.; Zhang, H.-J.; Zhao, Y.-C.; Li, X.-Y.; Wang, Y.-M.; Zhang, T.-T.; Xue, C.-H. N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis. Mar. Drugs 2023, 21, 39. https://doi.org/10.3390/md21010039

AMA Style

Zou H-Y, Zhang H-J, Zhao Y-C, Li X-Y, Wang Y-M, Zhang T-T, Xue C-H. N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis. Marine Drugs. 2023; 21(1):39. https://doi.org/10.3390/md21010039

Chicago/Turabian Style

Zou, Hong-Yu, Hui-Juan Zhang, Ying-Cai Zhao, Xiao-Yue Li, Yu-Ming Wang, Tian-Tian Zhang, and Chang-Hu Xue. 2023. "N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis" Marine Drugs 21, no. 1: 39. https://doi.org/10.3390/md21010039

APA Style

Zou, H.-Y., Zhang, H.-J., Zhao, Y.-C., Li, X.-Y., Wang, Y.-M., Zhang, T.-T., & Xue, C.-H. (2023). N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis. Marine Drugs, 21(1), 39. https://doi.org/10.3390/md21010039

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