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Open AccessArticle

Monarubins A–C from the Marine Shellfish-Associated Fungus Monascus ruber BB5

1
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
2
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
3
School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
4
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(2), 100; https://doi.org/10.3390/md18020100
Received: 14 January 2020 / Revised: 2 February 2020 / Accepted: 3 February 2020 / Published: 3 February 2020
Three new compounds, monarubins A–C (1, 6 and 13), together with ten known compounds, including four alkaloids (25), two isocoumarins (7 and 8) and four polyketides (912), were isolated from marine shellfish-associated fungus Monascus ruber BB5. The structures were determined on the basis of the 1D and 2D NMR, MS, UV and IR data. The absolute configurations of compounds 3, 6 and 13 were determined by ECD calculations. The NMR data of compounds deoxyhydroxyaspergillic acid (3) and 2-hydroxy-6-(1-hydroxy-1-methylpropyl)-3-sec-buthylpyrazine (4) were first reported. All of the isolated compounds were evaluated for their cytotoxic activities against human nasopharyngeal carcinoma cell lines CNE1, CNE2, SUNE1 and HONE1 and hepatocellular carcinoma cell lines QGY7701 and HepG2. Monarubin B (6) displayed potent cytotoxicities against the cancer cell lines HepG2 and QGY7701 with IC50 values of 1.72 and 0.71 μΜ, respectively; lunatinin (7) showed moderate cytotoxic activities against the cancer cell lines HepG2, QGY7701 and SUNE1 with the IC50 values of 9.60, 7.12 and 28.12 μΜ, respectively. View Full-Text
Keywords: Monascus ruber; marine shellfish; marine fungus; monarubin; cytotoxicity Monascus ruber; marine shellfish; marine fungus; monarubin; cytotoxicity
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MDPI and ACS Style

Ran, Y.-Q.; Lan, W.-J.; Qiu, Y.; Guo, Q.; Feng, G.-K.; Deng, R.; Zhu, X.-F.; Li, H.-J.; Dong, J. Monarubins A–C from the Marine Shellfish-Associated Fungus Monascus ruber BB5. Mar. Drugs 2020, 18, 100.

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