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Whole Genome Sequencing of the Blue Tilapia (Oreochromis aureus) Provides a Valuable Genetic Resource for Biomedical Research on Tilapias

1,2,†, 2,†, 3,†, 2,4, 2,4, 2,4, 2,4, 2,4 and 2,4,*
1
Center of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China
2
Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI Academy of Marine Sciences, BGI Marine, BGI, Shenzhen 518083, China
3
BGI Marine-Hainan, BGI Marine, BGI, Wenchang 571327, China
4
BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2019, 17(7), 386; https://doi.org/10.3390/md17070386
Received: 29 April 2019 / Revised: 21 June 2019 / Accepted: 26 June 2019 / Published: 28 June 2019
(This article belongs to the Special Issue Genetics of Marine Organisms Associated with Human Health)
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Abstract

Blue tilapia (Oreochromis aureus) has been an economically important fish in Asian countries. It can grow and reproduce in both freshwater and brackish water conditions, whereas it is also considered as a significant invasive species around the world. This species has been widely used as the hybridization parent(s) for tilapia breeding with a major aim to produce novel strains. However, available genomic resources are still limited for this important tilapia species. Here, we for the first time sequenced and assembled a draft genome for a seawater cultured blue tilapia (0.92 Gb), with 97.8% completeness and a scaffold N50 of 1.1 Mb, which suggests a relatively high quality of this genome assembly. We also predicted 23,117 protein-coding genes in the blue tilapia genome. Comparisons of predicted antimicrobial peptides between the blue tilapia and its close relative Nile tilapia proved that these immunological genes are highly similar with a genome-wide scattering distribution. As a valuable genetic resource, our blue tilapia genome assembly will benefit for biomedical researches and practical molecular breeding for high resistance to various diseases, which have been a critical problem in the aquaculture of tilapias. View Full-Text
Keywords: blue tilapia (Oreochromis aureus); whole genome sequencing; genome assembly; genome annotation; antimicrobial peptide blue tilapia (Oreochromis aureus); whole genome sequencing; genome assembly; genome annotation; antimicrobial peptide
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Bian, C.; Li, J.; Lin, X.; Chen, X.; Yi, Y.; You, X.; Zhang, Y.; Lv, Y.; Shi, Q. Whole Genome Sequencing of the Blue Tilapia (Oreochromis aureus) Provides a Valuable Genetic Resource for Biomedical Research on Tilapias. Mar. Drugs 2019, 17, 386.

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