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Open AccessFeature PaperArticle

Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite

1
Division of Environmental Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Chengam-ro, Nam-gu, Pohang 37673, Korea
2
Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 77 Chengam-ro, Nam-gu, Pohang 37673, Korea
3
Department of Chemistry, Institute for Molecular Science and Fusion Technology, Kangwon National University, Chuncheon 24341, Korea
4
Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 58, SE-100 44 Stockholm, Sweden
*
Authors to whom correspondence should be addressed.
These authors are equally contributed.
Mar. Drugs 2019, 17(6), 318; https://doi.org/10.3390/md17060318
Received: 10 May 2019 / Revised: 28 May 2019 / Accepted: 28 May 2019 / Published: 30 May 2019
(This article belongs to the Special Issue Marine Chitin 2019)
Although collagens from vertebrates are mainly used in regenerative medicine, the most elusive issue in the collagen-based biomedical scaffolds is its insufficient mechanical strength. To solve this problem, electrospun collagen composites with chitins were prepared and molecular interactions which are the cause of the mechanical improvement in the composites were investigated by two-dimensional correlation spectroscopy (2DCOS). The electrospun collagen is composed of two kinds of polymorphs, α- and β-chitin, showing different mechanical enhancement and molecular interactions due to different inherent configurations in the crystal structure, resulting in solvent and polymer susceptibility. The collagen/α-chitin has two distinctive phases in the composite, but β-chitin composite has a relatively homogeneous phase. The β-chitin composite showed better tensile strength with ~41% and ~14% higher strength compared to collagen and α-chitin composites, respectively, due to a favorable secondary interaction, i.e., inter- rather than intra-molecular hydrogen bonds. The revealed molecular interaction indicates that β-chitin prefers to form inter-molecular hydrogen bonds with collagen by rearranging their uncrumpled crystalline regions, unlike α-chitin. View Full-Text
Keywords: chitin; collagen; electrospinning; mechanical property; 2D correlation spectroscopy; polymorph chitin; collagen; electrospinning; mechanical property; 2D correlation spectroscopy; polymorph
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MDPI and ACS Style

Moon, H.; Choy, S.; Park, Y.; Jung, Y.M.; Koo, J.M.; Hwang, D.S. Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite. Mar. Drugs 2019, 17, 318.

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