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New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151

Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
University of Chinese Academy of Sciences, Beijing 100049, China
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
Key Biosensor Laboratory of Shandong Provinde, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250013, China
State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 262;
Received: 3 April 2019 / Revised: 29 April 2019 / Accepted: 30 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Natural Products from Marine Fungi)
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Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)-1), (±)-8-hydroxy-brevianamide R ((±)-2), and (±)-8-epihydroxy-brevianamide R ((±)-3), together with four known compounds, (±)-brevianamide R ((±)-4), versicolorin B (5) and averufin (6), were isolated from a marine-derived fungus strain Aspergillus versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. 1 is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against Candida albicans, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Bacillus Calmette-Guérin. Compounds 14 showed no activities against the pathogens, and compounds 5 and 6 showed moderate activities against S. aureus and methicillin-resistant S. aureus. View Full-Text
Keywords: marine-derived fungus; Aspergillus versicolor; diketopiperazine; antibacterial marine-derived fungus; Aspergillus versicolor; diketopiperazine; antibacterial

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Hu, J.; Li, Z.; Gao, J.; He, H.; Dai, H.; Xia, X.; Liu, C.; Zhang, L.; Song, F. New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151. Mar. Drugs 2019, 17, 262.

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