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New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151

1
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
4
Key Biosensor Laboratory of Shandong Provinde, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250013, China
5
State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(5), 262; https://doi.org/10.3390/md17050262
Received: 3 April 2019 / Revised: 29 April 2019 / Accepted: 30 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Natural Products from Marine Fungi)
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Abstract

Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)-1), (±)-8-hydroxy-brevianamide R ((±)-2), and (±)-8-epihydroxy-brevianamide R ((±)-3), together with four known compounds, (±)-brevianamide R ((±)-4), versicolorin B (5) and averufin (6), were isolated from a marine-derived fungus strain Aspergillus versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. 1 is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against Candida albicans, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Bacillus Calmette-Guérin. Compounds 14 showed no activities against the pathogens, and compounds 5 and 6 showed moderate activities against S. aureus and methicillin-resistant S. aureus. View Full-Text
Keywords: marine-derived fungus; Aspergillus versicolor; diketopiperazine; antibacterial marine-derived fungus; Aspergillus versicolor; diketopiperazine; antibacterial
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Hu, J.; Li, Z.; Gao, J.; He, H.; Dai, H.; Xia, X.; Liu, C.; Zhang, L.; Song, F. New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151. Mar. Drugs 2019, 17, 262.

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