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Open AccessArticle

Anthraquinone Derivatives from a Marine-Derived Fungus Sporendonema casei HDN16-802

1
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
3
Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(6), 334; https://doi.org/10.3390/md17060334
Received: 30 April 2019 / Revised: 28 May 2019 / Accepted: 29 May 2019 / Published: 4 June 2019
(This article belongs to the Special Issue Natural Products from Marine Fungi)
Five new anthraquinone derivatives, auxarthrols D–H (15), along with two known analogues (67), were obtained from the culture of the marine-derived fungus Sporendonema casei. Their structures, including absolute configurations, were established on the basis of NMR, HRESIMS, and circular dichroism (CD) spectroscopic techniques. Among them, compound 4 represents the second isolated anthraquinone derivative with a chlorine atom, which, with compound 6, are the first reported anthraquinone derivatives with anticoagulant activity. Compounds 1 and 3 showed cytotoxic activities with IC50 values from 4.5 μM to 22.9 μM, while compounds 1, 34, and 67 showed promising antibacterial activities with MIC values from 12.5 μM to 200 μM. In addition, compound 7 was discovered to display potential antitubercular activity for the first time. View Full-Text
Keywords: anthraquinone derivatives; Sporendonema casei; marine-derived fungus; cytotoxic activities; antibacterial activities anthraquinone derivatives; Sporendonema casei; marine-derived fungus; cytotoxic activities; antibacterial activities
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MDPI and ACS Style

Ge, X.; Sun, C.; Feng, Y.; Wang, L.; Peng, J.; Che, Q.; Gu, Q.; Zhu, T.; Li, D.; Zhang, G. Anthraquinone Derivatives from a Marine-Derived Fungus Sporendonema casei HDN16-802. Mar. Drugs 2019, 17, 334.

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