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Mar. Drugs 2019, 17(4), 201; https://doi.org/10.3390/md17040201

Antitumoral Effect of Laurinterol on 3D Culture of Breast Cancer Explants

1
Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), Av. Pedro de Alba s/n, 66450 San Nicolás de los Garza, Nuevo León, México
2
Instituto Universitario de Bio-Orgánica Antonio González (IUBO AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna (ULL), Avda. Astrofísico F. Sánchez, 2, 38206 La Laguna, Tenerife, Spain
3
Servicio de Oncología Ginecológica, Unidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia No. 23, Instituto Mexicano del Seguro Social (IMSS), Avenida Constitución y Félix U. Gómez s/n, Colonia Centro, 64000 Monterrey, Nuevo León, México
4
Departamento de Anatomía Patológica, Unidad Médica de Alta Especialidad, Hospital de Gineco- Obstetricia No. 23, Instituto Mexicano del Seguro Social (IMSS), Avenida Constitución y Félix U. Gómez s/n, Colonia Centro, 64000 Monterrey, Nuevo León, México
5
Centro de Investigación Biomédica del Noreste (CIBIN), Instituto Mexicano del Seguro Social (IMSS), Calle Jesús Dionisio González # 501, Col. Independencia, 64720 Monterrey, Nuevo León, México
6
División de Investigación en Salud, Unidad Médica de Alta Especialidad, Hospital de Cardiología No. 34, Instituto Mexicano del Seguro Social (IMSS), Av. Lincoln S/N esquina con Enfermera María de Jesús Candia, Col. Valle Verde 2do. Sector, 64360 Monterrey, Nuevo León, México
*
Authors to whom correspondence should be addressed.
Received: 22 February 2019 / Revised: 18 March 2019 / Accepted: 25 March 2019 / Published: 29 March 2019
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Abstract

Macroalgae represent an important source of bioactive compounds with a wide range of biotechnological applications. Overall, the discovery of effective cytotoxic compounds with pharmaceutical potential is a significant challenge, mostly because they are scarce in nature or their total synthesis is not efficient, while the bioprospecting models currently used do not predict clinical responses. Given this context, we used three-dimensional (3D) cultures of human breast cancer explants to evaluate the antitumoral effect of laurinterol, the major compound of an ethanolic extract of Laurencia johnstonii. To this end, we evaluated the metabolic and histopathological effects of the crude extract of L. johnstonii and laurinterol on Vero and MCF-7 cells, in addition to breast cancer explants. We observed a dose-dependent inhibition of the metabolic activity, as well as morphologic and nuclear changes characteristic of apoptosis. On the other hand, a reduced metabolic viability and marked necrosis areas were observed in breast cancer explants incubated with the crude extract, while explants treated with laurinterol exhibited a heterogeneous response which was associated with the individual response of each human tumor sample. This study supports the cytotoxic and antitumoral effects of laurinterol in in vitro cell cultures and in ex vivo organotypic cultures of human breast cancer explants. View Full-Text
Keywords: laurinterol; Laurencia; antitumoral; breast cancer explants; organotypic culture; ex vivo laurinterol; Laurencia; antitumoral; breast cancer explants; organotypic culture; ex vivo
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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García-Davis, S.; Viveros-Valdez, E.; Díaz-Marrero, A.R.; Fernández, J.J.; Valencia-Mercado, D.; Esquivel-Hernández, O.; Carranza-Rosales, P.; Carranza-Torres, I.E.; Guzmán-Delgado, N.E. Antitumoral Effect of Laurinterol on 3D Culture of Breast Cancer Explants. Mar. Drugs 2019, 17, 201.

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