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Marine Drugs
Volume 17
Issue 3
10.3390/md17030190
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Article

In Silico Analysis of Relationship between Proteins from Plastid Genome of Red Alga Palmaria sp. (Japan) and Angiotensin I Converting Enzyme Inhibitory Peptides

by
Yuya Kumagai
1,
Yoshikatsu Miyabe
2,
Tomoyuki Takeda
2,
Kohsuke Adachi
3,
Hajime Yasui
4 and
Hideki Kishimura
1,*
1
Laboratory of Marine Chemical Resource Development, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan
2
Chair of Marine Chemical Resource Development, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan
3
Laboratory of Aquatic Product Utilization, Graduate School of Agriculture, Kochi University, Monobeotsu 200, Nankoku, Kochi 783-8502, Japan
4
Laboratory of Humans and the Ocean, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(3), 190; https://doi.org/10.3390/md17030190
Submission received: 20 February 2019 / Revised: 19 March 2019 / Accepted: 20 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Bioinformatics of Marine Natural Products)
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Abstract

Plastid proteins are one of the main components in red algae. In order to clarify the angiotensin I converting enzyme (ACE) inhibitory peptides from red alga Palmaria sp. (Japan), we determined the plastid genome sequence. The genome possesses 205 protein coding genes, which were classified as genetic systems, ribosomal proteins, photosystems, adenosine triphosphate (ATP) synthesis, metabolism, transport, or unknown. After comparing ACE inhibitory peptides between protein sequences and a database, photosystems (177 ACE inhibitory peptides) were found to be the major source of ACE inhibitory peptides (total of 751). Photosystems consist of phycobilisomes, photosystem I, photosystem II, cytochrome complex, and a redox system. Among them, photosystem I (53) and II (51) were the major source of ACE inhibitory peptides. We found that the amino acid sequence of apcE (14) in phycobilisomes, psaA (18) and psaB (13) in photosystem I, and psbB (11) and psbC (10) in photosystem II covered a majority of bioactive peptide sequences. These results are useful for evaluating the bioactive peptides from red algae.
Keywords: dulse; Palmaria sp. (Japan); ACE inhibitory peptide; plastid genome dulse; Palmaria sp. (Japan); ACE inhibitory peptide; plastid genome
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MDPI and ACS Style

Kumagai, Y.; Miyabe, Y.; Takeda, T.; Adachi, K.; Yasui, H.; Kishimura, H. In Silico Analysis of Relationship between Proteins from Plastid Genome of Red Alga Palmaria sp. (Japan) and Angiotensin I Converting Enzyme Inhibitory Peptides. Mar. Drugs 2019, 17, 190. https://doi.org/10.3390/md17030190

AMA Style

Kumagai Y, Miyabe Y, Takeda T, Adachi K, Yasui H, Kishimura H. In Silico Analysis of Relationship between Proteins from Plastid Genome of Red Alga Palmaria sp. (Japan) and Angiotensin I Converting Enzyme Inhibitory Peptides. Marine Drugs. 2019; 17(3):190. https://doi.org/10.3390/md17030190

Chicago/Turabian Style

Kumagai, Yuya, Yoshikatsu Miyabe, Tomoyuki Takeda, Kohsuke Adachi, Hajime Yasui, and Hideki Kishimura. 2019. "In Silico Analysis of Relationship between Proteins from Plastid Genome of Red Alga Palmaria sp. (Japan) and Angiotensin I Converting Enzyme Inhibitory Peptides" Marine Drugs 17, no. 3: 190. https://doi.org/10.3390/md17030190

APA Style

Kumagai, Y., Miyabe, Y., Takeda, T., Adachi, K., Yasui, H., & Kishimura, H. (2019). In Silico Analysis of Relationship between Proteins from Plastid Genome of Red Alga Palmaria sp. (Japan) and Angiotensin I Converting Enzyme Inhibitory Peptides. Marine Drugs, 17(3), 190. https://doi.org/10.3390/md17030190

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