In Vitro Anticancer and Proapoptotic Activities of Steroidal Glycosides from the Starfish Anthenea aspera
AbstractNew marine glycoconjugates—the steroidal glycosides designated as anthenosides V–X (1–3)—and the seven previously known anthenosides E (4), G (5), J (6), K (7), S1 (8), S4 (9), and S6 (10) were isolated from the extract of the tropical starfish Anthenea aspera. The structures of 1–3 were elucidated by extensive NMR and ESIMS techniques. Glycoside 1 contains a rare 5α-cholest-8(14)-ene-3α,7β,16α-hydroxysteroidal nucleus. Compounds 2 and 3 were isolated as inseparable mixtures of epimers. All investigated compounds (1–10) at nontoxic concentrations inhibited colony formation of human melanoma RPMI-7951, breast cancer T-47D, and colorectal carcinoma HT-29 cells to a variable degree. The mixture of 6 and 7 possessed significant anticancer activity and induced apoptosis of HT-29 cells. The molecular mechanism of the proapoptotic action of this mixture was shown to be associated with the regulation of anti- and proapoptotic protein expression followed by the activation of initiator and effector caspases. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 1427 KB)
Share & Cite This Article
Malyarenko, T.V.; Malyarenko, O.S.; Kicha, A.A.; Ivanchina, N.V.; Kalinovsky, A.I.; Dmitrenok, P.S.; Ermakova, S.P.; Stonik, V.A. In Vitro Anticancer and Proapoptotic Activities of Steroidal Glycosides from the Starfish Anthenea aspera. Mar. Drugs 2018, 16, 420.
Malyarenko TV, Malyarenko OS, Kicha AA, Ivanchina NV, Kalinovsky AI, Dmitrenok PS, Ermakova SP, Stonik VA. In Vitro Anticancer and Proapoptotic Activities of Steroidal Glycosides from the Starfish Anthenea aspera. Marine Drugs. 2018; 16(11):420.Chicago/Turabian Style
Malyarenko, Timofey V.; Malyarenko, Olesya S.; Kicha, Alla A.; Ivanchina, Natalia V.; Kalinovsky, Anatoly I.; Dmitrenok, Pavel S.; Ermakova, Svetlana P.; Stonik, Valentin A. 2018. "In Vitro Anticancer and Proapoptotic Activities of Steroidal Glycosides from the Starfish Anthenea aspera." Mar. Drugs 16, no. 11: 420.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.