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Mar. Drugs 2018, 16(11), 420; https://doi.org/10.3390/md16110420

In Vitro Anticancer and Proapoptotic Activities of Steroidal Glycosides from the Starfish Anthenea aspera

1
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
2
Far Eastern Federal University, Sukhanova Str. 8, 690000 Vladivostok, Russia
*
Author to whom correspondence should be addressed.
Received: 8 October 2018 / Revised: 24 October 2018 / Accepted: 25 October 2018 / Published: 1 November 2018
(This article belongs to the Special Issue Marine Glycoconjugates: Trends and Perspectives)
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Abstract

New marine glycoconjugates—the steroidal glycosides designated as anthenosides V–X (13)—and the seven previously known anthenosides E (4), G (5), J (6), K (7), S1 (8), S4 (9), and S6 (10) were isolated from the extract of the tropical starfish Anthenea aspera. The structures of 13 were elucidated by extensive NMR and ESIMS techniques. Glycoside 1 contains a rare 5α-cholest-8(14)-ene-3α,7β,16α-hydroxysteroidal nucleus. Compounds 2 and 3 were isolated as inseparable mixtures of epimers. All investigated compounds (110) at nontoxic concentrations inhibited colony formation of human melanoma RPMI-7951, breast cancer T-47D, and colorectal carcinoma HT-29 cells to a variable degree. The mixture of 6 and 7 possessed significant anticancer activity and induced apoptosis of HT-29 cells. The molecular mechanism of the proapoptotic action of this mixture was shown to be associated with the regulation of anti- and proapoptotic protein expression followed by the activation of initiator and effector caspases. View Full-Text
Keywords: starfish; Anthenea aspera; steroidal glycosides; colony formation; apoptosis; Bcl-2 proteins starfish; Anthenea aspera; steroidal glycosides; colony formation; apoptosis; Bcl-2 proteins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Malyarenko, T.V.; Malyarenko, O.S.; Kicha, A.A.; Ivanchina, N.V.; Kalinovsky, A.I.; Dmitrenok, P.S.; Ermakova, S.P.; Stonik, V.A. In Vitro Anticancer and Proapoptotic Activities of Steroidal Glycosides from the Starfish Anthenea aspera. Mar. Drugs 2018, 16, 420.

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