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Mar. Drugs 2018, 16(11), 398; https://doi.org/10.3390/md16110398

Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model

1
Department of Internal Medicine, Dong-A University, Busan 49201, Korea
2
Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, Dong-A University, Busan 49315, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 18 September 2018 / Revised: 22 October 2018 / Accepted: 22 October 2018 / Published: 23 October 2018
(This article belongs to the Collection Marine Drugs in the Management of Metabolic Diseases)
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Abstract

Six transmembrane protein of prostate 2 (STAMP2) is a critical modulator of inflammation and metabolism in adipose tissue. There are no data on the expression of STAMP2 in chronic kidney disease, which is an inflammatory disease related to metabolic disorders. This study aimed to investigate STAMP2 expression in the kidney and heart in 5/6 nephrectomy (Nx) rats, and the effect of omega-3 fatty acid (FA) on STAMP2 expression. Male Sprague Dawley rats were divided into three groups: sham control (0.9% saline), 5/6 Nx (0.9% saline), and 5/6 Nx treated with omega-3 FA (300 mg per kg per day by gastric gavage). The expression of STAMP2 in the kidney and heart were examined by western blotting. Serum creatinine levels were higher in 5/6 Nx rats than in controls. Compared with sham controls, the expression of IκB, NF-κB, NOX4, SREBP-1, and LXR were upregulated and STAMP2 and phosphorylated-AMPK expression were downregulated in the kidney and heart of 5/6 Nx rats. Omega-3 FA supplementation prevented these changes in biomarkers related to inflammation and metabolic lipid disorders. Omega 3-FA supplementation induced the upregulation of STAMP2 protein in 5/6 Nx rats, which was associated with an attenuation of inflammation- and metabolic disease-related markers. View Full-Text
Keywords: omega-3 fatty acid; STAMP2; heart; kidney omega-3 fatty acid; STAMP2; heart; kidney
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Lee, H.W.; Lee, S.M.; Lee, M.H.; Son, Y.K.; Kim, S.E.; An, W.S. Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model. Mar. Drugs 2018, 16, 398.

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