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Mar. Drugs 2018, 16(10), 343; https://doi.org/10.3390/md16100343

Two Novel Aspochalasins from the Gut Fungus Aspergillus sp. Z4

Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan 316021, China
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Received: 2 September 2018 / Revised: 13 September 2018 / Accepted: 18 September 2018 / Published: 20 September 2018
(This article belongs to the Special Issue Natural Products from Marine Fungi)
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Abstract

Two novel aspochalasins, tricochalasin A (1) and aspochalasin A2 (2), along with three known compounds (35) have been isolated from the different culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. Compound 1 contains a rare 5/6/6 tricyclic ring fused with the aspochalasin skeleton. The structures were determined on the basis of electrospray ionisation mass spectroscopy (ESIMS), nuclear magnetic resonance (NMR) spectral data, and the absolute configurations were further confirmed by modified Mosher’s method. Cytotoxicity against the prostate cancer PC3 cell line were assayed by the MTT method. Compound 3 showed strong activity while the remaining compounds showed weak activity. View Full-Text
Keywords: aspochalasin; tricyclic fused; gut fungus; cytotoxicity aspochalasin; tricyclic fused; gut fungus; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Li, X.; Ding, W.; Wang, P.; Xu, J. Two Novel Aspochalasins from the Gut Fungus Aspergillus sp. Z4. Mar. Drugs 2018, 16, 343.

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