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Open AccessArticle

Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum

by Yanchao Xu 1,2,3,†, Cong Wang 2,4,†, Haishan Liu 2, Guoliang Zhu 2, Peng Fu 2,3, Liping Wang 1,2,* and Weiming Zhu 1,2,3,*
1
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
2
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
3
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China
4
Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530006, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Mar. Drugs 2018, 16(10), 363; https://doi.org/10.3390/md16100363
Received: 31 August 2018 / Revised: 25 September 2018 / Accepted: 27 September 2018 / Published: 1 October 2018
(This article belongs to the Special Issue Natural Products from Marine Fungi)
Four new meroterpenoids 14 and four new isocoumarinoids 58, along with five known isocoumarinoids (913), were isolated from the fungus Myrothecium sp. OUCMDZ-2784 associated with the salt-resistant medicinal plant, Apocynum venetum (Apocynaceae). Their structures were elucidated by means of spectroscopic analysis, X-ray crystallography, ECD spectra and quantum chemical calculations. Compounds 15, 7, 9 and 10 showed weak α-glucosidase inhibition with the IC50 values of 0.50, 0.66, 0.058, 0.20, 0.32, 0.036, 0.026 and 0.37 mM, respectively. View Full-Text
Keywords: endophytic fungus; Myrothecium sp.; meroterpenoids; isocoumarinoids; α-glucosidase inhibitors; salt-resistant plant; Apocynum venetum endophytic fungus; Myrothecium sp.; meroterpenoids; isocoumarinoids; α-glucosidase inhibitors; salt-resistant plant; Apocynum venetum
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MDPI and ACS Style

Xu, Y.; Wang, C.; Liu, H.; Zhu, G.; Fu, P.; Wang, L.; Zhu, W. Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum. Mar. Drugs 2018, 16, 363.

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