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Volume 59
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Case Report

Post VV-ECMO Weaning Hyperinflammation—Can Prophylactic Hemoadsorption Treatment Prevent Complications?

by
Pedja Kovacevic
1,2,*,
Sasa Dragic
1,2,
Milka Jandric
1,
Danica Momcicevic
1,2,
Sandra Topolovac
1,
Vedrana Malesevic
1,
Tijana Kovacevic
1,2,
Marijana Matejic-Spasic
3,
Tanja Knezevic
1 and
Biljana Zlojutro
1,2
1
Medical Intensive Care Unit, University Clinical Centre of the Republic of Srpska, 78000 Banja Luka, Bosnia and Herzegovina
2
Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, Bosnia and Herzegovina
3
CytoSorbents Europe GmbH, 12587 Berlin, Germany
*
Author to whom correspondence should be addressed.
Medicina 2023, 59(10), 1818; https://doi.org/10.3390/medicina59101818
Submission received: 23 August 2023 / Revised: 23 September 2023 / Accepted: 28 September 2023 / Published: 12 October 2023
(This article belongs to the Section Intensive Care/ Anesthesiology)
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Abstract

Acute respiratory distress syndrome (ARDS) is a severe clinical condition characterized by acute respiratory failure and a high mortality risk despite conventional mechanical ventilatory support. Veno-venous extracorporeal membrane oxygenation (vvECMO) has emerged as an effective life-support technology for patients with ARDS. However, complications may arise following the decannulation of vvECMO, with a relatively frequent development of systemic hyperinflammation (SHI). Among the various treatment strategies for SHI, the use of hemoadsorption with CytoSorb® has shown promising results in removing excessive levels of cytokines and attenuating the hyperinflammatory response. In this case series, we present three critically ill patients with ARDS secondary to pneumonia who underwent vvECMO and subsequently received prophylactic hemoadsorption with CytoSorb® following decannulation as a part of our clinical practice. This case series aims to describe the potential positive effects of hemoadsorption in preventing the development of SHI after vvECMO decannulation in ARDS patients.
Keywords: ECMO; hyperinflammation; hemoadsorption; CytoSorb ECMO; hyperinflammation; hemoadsorption; CytoSorb

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MDPI and ACS Style

Kovacevic, P.; Dragic, S.; Jandric, M.; Momcicevic, D.; Topolovac, S.; Malesevic, V.; Kovacevic, T.; Matejic-Spasic, M.; Knezevic, T.; Zlojutro, B. Post VV-ECMO Weaning Hyperinflammation—Can Prophylactic Hemoadsorption Treatment Prevent Complications? Medicina 2023, 59, 1818. https://doi.org/10.3390/medicina59101818

AMA Style

Kovacevic P, Dragic S, Jandric M, Momcicevic D, Topolovac S, Malesevic V, Kovacevic T, Matejic-Spasic M, Knezevic T, Zlojutro B. Post VV-ECMO Weaning Hyperinflammation—Can Prophylactic Hemoadsorption Treatment Prevent Complications? Medicina. 2023; 59(10):1818. https://doi.org/10.3390/medicina59101818

Chicago/Turabian Style

Kovacevic, Pedja, Sasa Dragic, Milka Jandric, Danica Momcicevic, Sandra Topolovac, Vedrana Malesevic, Tijana Kovacevic, Marijana Matejic-Spasic, Tanja Knezevic, and Biljana Zlojutro. 2023. "Post VV-ECMO Weaning Hyperinflammation—Can Prophylactic Hemoadsorption Treatment Prevent Complications?" Medicina 59, no. 10: 1818. https://doi.org/10.3390/medicina59101818

APA Style

Kovacevic, P., Dragic, S., Jandric, M., Momcicevic, D., Topolovac, S., Malesevic, V., Kovacevic, T., Matejic-Spasic, M., Knezevic, T., & Zlojutro, B. (2023). Post VV-ECMO Weaning Hyperinflammation—Can Prophylactic Hemoadsorption Treatment Prevent Complications? Medicina, 59(10), 1818. https://doi.org/10.3390/medicina59101818

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