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Volume 57
Issue 9
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Article

Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease

by
Victoria Monge-García
1,
María-Salud García-Ayllón
2,3,4,*,
Javier Sáez-Valero
2,3,5,
José Sánchez-Payá
5,6,
Francisco Navarrete-Rueda
3,
Jorge Manzanares-Robles
3,
Ruth Gasparini-Berenguer
7,
Raquel Romero-Lorenzo
7,
María Angeles Cortés-Gómez
3 and
José-Antonio Monge-Argilés
5,7,*
1
Rehabilitation Service, University General Hospital of Alicante, 03010 Alicante, Spain
2
Research Unit, University General Hospital of Elche, FISABIO, 03456 Elche, Spain
3
Instituto de Neurociencias de Alicante, Miguel Hernández-CSIC, San Juan de Alicante, 03550 Alicante, Spain
4
Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), San Juan de Alicante, 03550 Alicante, Spain
5
Institute of Sanitary and Biomedical Research of Alicante (ISABIAL), 03010 Alicante, Spain
6
Preventive Medicine Service, University General Hospital of Alicante, 03010 Alicante, Spain
7
Neurology Department, University General Hospital of Alicante, 03010 Alicante, Spain
*
Authors to whom correspondence should be addressed.
Medicina 2021, 57(9), 954; https://doi.org/10.3390/medicina57090954
Submission received: 21 July 2021 / Revised: 31 August 2021 / Accepted: 7 September 2021 / Published: 10 September 2021
(This article belongs to the Special Issue Alzheimer's Disease and Related Dementias: Current Knowledge, Advances, and Future Direction)
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Abstract

Background: Alzheimer’s disease (AD) is characterized by the presence of β-amyloid plaques and neurofibrillary tangles, while Lewy body dementia (LBD) is characterized by α-synuclein (α-syn) inclusions. Some authors examine α-syn protein in the neurodegeneration process of AD and propose to consider cerebrospinal fluid (CSF) α-syn as a possible additional biomarker to the so-called “core” of AD. Objective: To determine whether there is a correlation between α-syn levels and “core” AD biomarkers in patients with mild cognitive impairment (MCI). Materials and methods: In total, 81 patients in the early stages of MCI were selected from the outpatient dementia consultation in Alicante General Hospital. Using a cross-sectional case–control design, patients were analyzed in four groups: stable MCI (MCIs; n = 25), MCI due to AD (MCI-AD; n = 32), MCI due to LBD (MCI-LBD; n = 24) and a control group of patients with acute or chronic headache (Ctrl; n = 18). Correlation between CSF protein levels in the different groups was assessed by the Rho Spearman test. Results: We found positive correlations between T-tau protein and α-syn (ρ = 0.418; p value < 0.05) and p-tau181p and α-syn (ρ = 0.571; p value < 0.05) exclusively in the MCI-AD group. Conclusion: The correlation found between α-syn and tau proteins in the first stages of AD support the involvement of α-syn in the pathogenesis of AD. This result may have clinical and diagnostic implications, as well as help to apply the new concept of “precision medicine” in patients with MCI.
Keywords: Alzheimer’s; biomarker; Lewy body disease; mild cognitive impairment; α-synuclein Alzheimer’s; biomarker; Lewy body disease; mild cognitive impairment; α-synuclein

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MDPI and ACS Style

Monge-García, V.; García-Ayllón, M.-S.; Sáez-Valero, J.; Sánchez-Payá, J.; Navarrete-Rueda, F.; Manzanares-Robles, J.; Gasparini-Berenguer, R.; Romero-Lorenzo, R.; Cortés-Gómez, M.A.; Monge-Argilés, J.-A. Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease. Medicina 2021, 57, 954. https://doi.org/10.3390/medicina57090954

AMA Style

Monge-García V, García-Ayllón M-S, Sáez-Valero J, Sánchez-Payá J, Navarrete-Rueda F, Manzanares-Robles J, Gasparini-Berenguer R, Romero-Lorenzo R, Cortés-Gómez MA, Monge-Argilés J-A. Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease. Medicina. 2021; 57(9):954. https://doi.org/10.3390/medicina57090954

Chicago/Turabian Style

Monge-García, Victoria, María-Salud García-Ayllón, Javier Sáez-Valero, José Sánchez-Payá, Francisco Navarrete-Rueda, Jorge Manzanares-Robles, Ruth Gasparini-Berenguer, Raquel Romero-Lorenzo, María Angeles Cortés-Gómez, and José-Antonio Monge-Argilés. 2021. "Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease" Medicina 57, no. 9: 954. https://doi.org/10.3390/medicina57090954

APA Style

Monge-García, V., García-Ayllón, M.-S., Sáez-Valero, J., Sánchez-Payá, J., Navarrete-Rueda, F., Manzanares-Robles, J., Gasparini-Berenguer, R., Romero-Lorenzo, R., Cortés-Gómez, M. A., & Monge-Argilés, J.-A. (2021). Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease. Medicina, 57(9), 954. https://doi.org/10.3390/medicina57090954

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