Next Article in Journal
Genetic and Environmental Structure of Altruism Characterized by Recipients in Relation to Personality
Previous Article in Journal
Blood Pressure Control and Antihypertensive Treatment among Hemodialysis Patients—Retrospective Single Center Experience
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Medicina
Volume 57
Issue 6
10.3390/medicina57060592
medicina-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Case Report

Frostbite and Cold Agglutinin Disease: Coexistence of Two Entities Leading to Poor Clinical Outcomes

by
Noel Lorenzo-Villalba
1,*,
Emmanuel Andres
1,
Javier Guerrero-Niño
2,
Edward Nasco
1,
Jessy Cattelan
1,
Xavier Jannot
1 and
Marie-Pierre Ledoux
3
1
Service de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France
2
Service des Urgences, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France
3
Service d’Hématologie, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France
*
Author to whom correspondence should be addressed.
Medicina 2021, 57(6), 592; https://doi.org/10.3390/medicina57060592
Submission received: 6 May 2021 / Revised: 28 May 2021 / Accepted: 7 June 2021 / Published: 8 June 2021
Browse Figures
Versions Notes

Abstract

An 83-year-old woman was admitted to the emergency department for a 7-day history of fatigue and progressive cyanosis in the feet and hands after cold exposure despite physical protective measures. Upon arrival, the patient presented with necrotic cutaneous lesions in both hands and distal lower extremities. Upon admission, hemoglobin was 7.6 g/dL and laboratory tests were consistent with cold agglutinin disease (CAD), the presence of monoclonal IgM, and flow cytometry consistent with lymphoplasmacytic lymphoma, but MYD88 L265P mutation was negative. The patient required blood transfusion, resulting in stabilized hemoglobin and a decrease in markers of hemolysis. Treatment with aspirin 250 mg daily and intravenous iloprost 0.5 mL/h was initiated with a poor clinical response at day 4. Amputation was required. Plasma exchange was performed and chemotherapy with rituximab and bendamustine was initiated. The clinical course was marked by further necrosis, prompting discussions regarding an additional amputation that was not performed considering the high surgical risk and refusal by the patient. Supportive treatment was initiated, and the patient expired one month after hospital admission.
Keywords: frostbite; cold agglutinin disease; amputation frostbite; cold agglutinin disease; amputation

Share and Cite

MDPI and ACS Style

Lorenzo-Villalba, N.; Andres, E.; Guerrero-Niño, J.; Nasco, E.; Cattelan, J.; Jannot, X.; Ledoux, M.-P. Frostbite and Cold Agglutinin Disease: Coexistence of Two Entities Leading to Poor Clinical Outcomes. Medicina 2021, 57, 592. https://doi.org/10.3390/medicina57060592

AMA Style

Lorenzo-Villalba N, Andres E, Guerrero-Niño J, Nasco E, Cattelan J, Jannot X, Ledoux M-P. Frostbite and Cold Agglutinin Disease: Coexistence of Two Entities Leading to Poor Clinical Outcomes. Medicina. 2021; 57(6):592. https://doi.org/10.3390/medicina57060592

Chicago/Turabian Style

Lorenzo-Villalba, Noel, Emmanuel Andres, Javier Guerrero-Niño, Edward Nasco, Jessy Cattelan, Xavier Jannot, and Marie-Pierre Ledoux. 2021. "Frostbite and Cold Agglutinin Disease: Coexistence of Two Entities Leading to Poor Clinical Outcomes" Medicina 57, no. 6: 592. https://doi.org/10.3390/medicina57060592

APA Style

Lorenzo-Villalba, N., Andres, E., Guerrero-Niño, J., Nasco, E., Cattelan, J., Jannot, X., & Ledoux, M.-P. (2021). Frostbite and Cold Agglutinin Disease: Coexistence of Two Entities Leading to Poor Clinical Outcomes. Medicina, 57(6), 592. https://doi.org/10.3390/medicina57060592

Article Metrics

Back to TopTop