Syncope Time Frames for Adverse Events after Emergency Department Presentation: An Individual Patient Data Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Inclusion Criteria
2.2. Outcomes and Definitions
2.3. Statistical Analysis
3. Results
3.1. Study Selection and Characteristics
3.2. Data Synthesis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study | N of Patients | Mean Age (SD) (Years) | N of Females (%) | N of Admitted (%) |
---|---|---|---|---|
Sun_2007 | 312 | 56 (24) | 179 (57) | 182 (58) |
Costantino_2008 | 689 | 64 (18) | 386 (56) | 236 (34) |
Ungar_2010 | 371 | 66 (21) | 168 (45) | 144 (39) |
Reed_2011 | 1100 | 63 (22) | 587 (53) | 538 (49) |
Pérez-Rodon_2014 | 616 | 57 (20) | 259 (42) | 154 (25) |
Numeroso_2016 | 347 | 73 (14) | 162 (47) | 157 (45) |
Thiruganasambandamoorthy_2016 | 6454 | 53 (23) | 3526 (55) | 789 (12) |
Solbiati_2020 | 345 | 65 (20) | 171 (50) | 102 (30) |
Probst_2020 | 2035 | 73 (9) | 989 (49) | 1682 (83) |
N of Studies | N of Patients with Events | N of Patients | Pooled Rate (%) | 95% CI (%) | I2 (%) | |
---|---|---|---|---|---|---|
24 h | 8 | 545 | 11,653 | 5.1 | 3.4–7.7 | 94 |
72 h | 7 | 602 | 10,553 | 7.0 | 4.9–9.9 | 93 |
7–10 days | 8 | 766 | 11,284 | 8.4 | 6.2–11.3 | 94 |
1 month | 8 | 902 | 11,175 | 10.3 | 7.8–13.3 | 93 |
1 year | 5 | 599 | 2917 | 21.3 | 15.8–28.0 | 94 |
N of Studies | N of Events | N of Patients | Pooled Rate (%) | 95% CI (%) | I2 (%) | ||
---|---|---|---|---|---|---|---|
Death | |||||||
24 h | 8 | 13 | 11,653 | 0.2 | 0.1–0.5 | 62 | |
72 h | 7 | 19 | 10,553 | 0.3 | 0.1–0.7 | 72 | |
7–10 days | 8 | 40 | 11,284 | 0.5 | 0.3–0.9 | 69 | |
1 month | 8 | 81 | 11,175 | 1.0 | 0.6–1.7 | 80 | |
1 year | 5 | 177 | 2917 | 5.9 | 4.5–7.7 | 66 | |
Arrhythmia | |||||||
24 h | 8 | 388 | 11,653 | 3.1 | 2.0–4.9 | 91 | |
72 h | 7 | 450 | 10,553 | 4.8 | 3.5–6.7 | 88 | |
7–10 days | 8 | 582 | 11,284 | 5.8 | 4.2–7.9 | 91 | |
1 month | 8 | 676 | 11,175 | 6.9 | 5.3–9.1 | 90 | |
1 year | 5 | 282 | 2917 | 9.9 | 5.5–17.1 | 96 | |
PM or ICD implant | |||||||
24 h | 6 | 86 | 10,593 | 0.6 | 0.3–1.4 | 78 | |
72 h | 5 | 123 | 9493 | 1.4 | 0.8–2.3 | 79 | |
7–10 days | 7 | 228 | 10,913 | 2.3 | 1.5–3.5 | 87 | |
1 month | 7 | 273 | 10,804 | 3.0 | 2.0–4.5 | 89 | |
1 year | 5 | 107 | 2917 | 3.6 | 2.5–5.2 | 73 |
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Furlan, L.; Trombetta, L.; Casazza, G.; Dipaola, F.; Furlan, R.; Marta, C.; Numeroso, F.; Pérez-Rodon, J.; Quinn, J.V.; Reed, M.J.; et al. Syncope Time Frames for Adverse Events after Emergency Department Presentation: An Individual Patient Data Meta-Analysis. Medicina 2021, 57, 1235. https://doi.org/10.3390/medicina57111235
Furlan L, Trombetta L, Casazza G, Dipaola F, Furlan R, Marta C, Numeroso F, Pérez-Rodon J, Quinn JV, Reed MJ, et al. Syncope Time Frames for Adverse Events after Emergency Department Presentation: An Individual Patient Data Meta-Analysis. Medicina. 2021; 57(11):1235. https://doi.org/10.3390/medicina57111235
Chicago/Turabian StyleFurlan, Ludovico, Lucia Trombetta, Giovanni Casazza, Franca Dipaola, Raffaello Furlan, Chiara Marta, Filippo Numeroso, Jordi Pérez-Rodon, James V. Quinn, Matthew J. Reed, and et al. 2021. "Syncope Time Frames for Adverse Events after Emergency Department Presentation: An Individual Patient Data Meta-Analysis" Medicina 57, no. 11: 1235. https://doi.org/10.3390/medicina57111235