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Electrocardiographic Patterns in Patients with Neurally Mediated Syncope
 
 
Article
Peer-Review Record

Syncope Time Frames for Adverse Events after Emergency Department Presentation: An Individual Patient Data Meta-Analysis

Medicina 2021, 57(11), 1235; https://doi.org/10.3390/medicina57111235
by Ludovico Furlan 1, Lucia Trombetta 2, Giovanni Casazza 3, Franca Dipaola 4, Raffaello Furlan 4, Chiara Marta 1, Filippo Numeroso 5, Jordi Pérez-Rodon 6, James V. Quinn 7, Matthew J. Reed 8, Robert S. Sheldon 9, Win-Kuang Shen 10, Benjamin C. Sun 11, Venkatesh Thiruganasambandamoorthy 12, Andrea Ungar 13, Giorgio Costantino 1,3 and Monica Solbiati 1,3,* on behalf of the SYNERGI (SYNcope Expert Research Group International)
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Medicina 2021, 57(11), 1235; https://doi.org/10.3390/medicina57111235
Submission received: 27 September 2021 / Revised: 4 November 2021 / Accepted: 10 November 2021 / Published: 12 November 2021
(This article belongs to the Special Issue Syncope in the Emergency Department)

Round 1

Reviewer 1 Report

The paper is well written, easy to follow and addresses an interesting topic.  The introduction section could be more extended.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

The authors performed a meta-analysis concerning the incidence and time frames of adverse events in adult syncope patients who presented to the ED. The manuscript is well written and leads to reasonable conclusion. This information seems to be useful in the clinical practice, especially in the ED. However, there are a few concerns for acceptance.

  1. This study included adult patients who referred to the ED for syncope. Therefore, the authors need to present the study population in the title: e.g. an individual patient data in the ED meta-analysis.
  2. The definition of “arrhythmia” or “arrhythmic events” is unclear. It may be included “bradyarrhythmias and supraventricular arrhythmias” not included “ventricular tachyarrhythmias” as described page 7, line 166-167. Please make sure the definition of “arrhythmia” or “arrhythmic events” and describe it in the definition section of the manuscript.

Author Response

Please see the attachment

Author Response File: Author Response.docx

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