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Article

Serum Angiopoietin-like Protein 3 Level Is Associated with Peripheral Arterial Stiffness in Patients with Coronary Artery Disease

by 1,†, 1,2,†, 1,2,3,* and 1,3,4,*
1
Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan
2
Division of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan
3
School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
4
Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Tomasz Zieliński
Medicina 2021, 57(10), 1011; https://doi.org/10.3390/medicina57101011
Received: 7 August 2021 / Revised: 19 September 2021 / Accepted: 22 September 2021 / Published: 25 September 2021
Background and Objectives: Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein regulating lipid metabolism. This study evaluated the relationship between serum ANGPTL3 level and peripheral arterial stiffness (PAS) in patients with coronary artery disease (CAD). Materials and Methods: Fasting blood samples were collected from 95 CAD patients. PAS was defined as left or right brachial-ankle pulse wave velocity (baPWV) > 18.0 m/s by an oscillometric method. Serum ANGPTL3 levels were assessed using a commercial enzyme-linked immunosorbent assay kit. Results: Seventeen CAD patients (17.9%) had PAS. Patients with PAS had a significantly higher percentage of diabetes (p = 0.002), older age (p = 0.030), higher systolic blood pressure (p = 0.016), higher fasting glucose (p = 0.008), serum C-reactive protein (p = 0.002), and ANGPTL3 level (p = 0.001) than those without PAS. After multivariable logistic regression analysis, serum ANGPTL3 level (Odds ratio (OR): 1.004, 95% confidence interval (CI): 1.000–1.007, p = 0.041) is still independently associated with PAS in CAD patients. The receiver operating characteristic curve for PAS prediction revealed that the area under the curve for ANGPTL3 level was 0.757 (95% CI: 0.645–0.870, p < 0.001). Conclusions: Serum fasting ANGPTL3 level is positively associated with PAS in CAD patients. Further studies are required for clarification. View Full-Text
Keywords: angiopoietin-like protein 3; peripheral arterial stiffness; brachial-ankle pulse wave velocity; coronary artery disease angiopoietin-like protein 3; peripheral arterial stiffness; brachial-ankle pulse wave velocity; coronary artery disease
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MDPI and ACS Style

Hsiao, C.-H.; Chen, Y.-C.; Wang, J.-H.; Hsu, B.-G. Serum Angiopoietin-like Protein 3 Level Is Associated with Peripheral Arterial Stiffness in Patients with Coronary Artery Disease. Medicina 2021, 57, 1011. https://doi.org/10.3390/medicina57101011

AMA Style

Hsiao C-H, Chen Y-C, Wang J-H, Hsu B-G. Serum Angiopoietin-like Protein 3 Level Is Associated with Peripheral Arterial Stiffness in Patients with Coronary Artery Disease. Medicina. 2021; 57(10):1011. https://doi.org/10.3390/medicina57101011

Chicago/Turabian Style

Hsiao, Chien-Hao, Yu-Chih Chen, Ji-Hung Wang, and Bang-Gee Hsu. 2021. "Serum Angiopoietin-like Protein 3 Level Is Associated with Peripheral Arterial Stiffness in Patients with Coronary Artery Disease" Medicina 57, no. 10: 1011. https://doi.org/10.3390/medicina57101011

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