Next Article in Journal
Two Lithuanian Cases of Classical Galactosemia with a Literature Review: A Novel GALT Gene Mutation Identified
Previous Article in Journal
Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone
Article

Major Clues and Pitfalls in the Differential Diagnosis of Parathyroid and Thyroid Lesions Using Fine Needle Aspiration Cytology

1
Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea
2
Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and Technology, Seoul 01811, Korea
3
Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul 0182, Korea
4
Radiological & Medico-Oncological Sciences, University of Science & Technology, Daejeon 34113, Korea
5
Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology, Seoul 01811, Korea
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(11), 558; https://doi.org/10.3390/medicina56110558
Received: 25 September 2020 / Revised: 20 October 2020 / Accepted: 21 October 2020 / Published: 24 October 2020
Background: It is difficult to distinguish parathyroid lesions (PLs) from thyroid lesions using fine needle aspiration cytology (FNAC) because of their proximity and their similar cytomorphological features. Methods: FNAC smears of 46 patients with pathologically proven PLs that were histologically diagnosed as parathyroid adenoma (PA, n = 35), parathyroid hyperplasia (PH, n = 3), atypical parathyroid adenoma (APA, n = 1), and parathyroid carcinoma (PC, n = 7) were retrospectively reviewed and analyzed. Results: Our initial cytological diagnoses indicated correct diagnoses in 31 of 46 PL patients (67%). The 15 erroneous diagnoses were 5 patients with non-specific benign disease (11%), 4 with nodular hyperplasia of the thyroid (9%), 5 with atypical cells (11%), and 1 with a metastatic papillary thyroid carcinoma (2%). Follicular pattern, papillary structures, colloid-like material, and macrophages, which often suggest thyroid lesions, were also present in some PLs. We found that branching capillaries along the papillary structures, stippled nuclear chromatin, and frequent occurrence of naked nuclei were useful for determining a parathyroid origin. Conclusions: It is important to be aware that PLs are frequently mistaken for thyroid lesions based on FNAC. The specific and unique characteristics of PLs identified here may be helpful in diagnosis. View Full-Text
Keywords: parathyroid lesion; thyroid lesion; fine needle aspiration cytology; diagnostic pitfalls parathyroid lesion; thyroid lesion; fine needle aspiration cytology; diagnostic pitfalls
Show Figures

Figure 1

MDPI and ACS Style

Ha, H.J.; Kim, E.J.; Kim, J.-S.; Shin, M.-S.; Noh, I.; Park, S.; Koh, J.S.; Lee, S.-S. Major Clues and Pitfalls in the Differential Diagnosis of Parathyroid and Thyroid Lesions Using Fine Needle Aspiration Cytology. Medicina 2020, 56, 558. https://doi.org/10.3390/medicina56110558

AMA Style

Ha HJ, Kim EJ, Kim J-S, Shin M-S, Noh I, Park S, Koh JS, Lee S-S. Major Clues and Pitfalls in the Differential Diagnosis of Parathyroid and Thyroid Lesions Using Fine Needle Aspiration Cytology. Medicina. 2020; 56(11):558. https://doi.org/10.3390/medicina56110558

Chicago/Turabian Style

Ha, Hwa J., Eun J. Kim, Jung-Soon Kim, Myung-Soon Shin, Insup Noh, Sunhoo Park, Jae S. Koh, and Seung-Sook Lee. 2020. "Major Clues and Pitfalls in the Differential Diagnosis of Parathyroid and Thyroid Lesions Using Fine Needle Aspiration Cytology" Medicina 56, no. 11: 558. https://doi.org/10.3390/medicina56110558

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop