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Review

Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone

1
College of Pharmacy, Roseman University of Health Sciences, South Jordan, UT 84096, USA
2
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, South Dakota State University, Brookings, SD 57007, USA
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(11), 557; https://doi.org/10.3390/medicina56110557
Received: 14 September 2020 / Revised: 20 October 2020 / Accepted: 21 October 2020 / Published: 23 October 2020
About 40–70% of drug molecules in the clinical development pipeline suffer from one of either low aqueous solubility, poor absorption, or extremely low bioavailability. Approximately 75% of the world population relies on traditional therapies and therefore there has been a growing interest in the utilization of natural compounds. Zerumbone is one such natural compound, classified as a sesquiterpenoid that is extracted from the essential volatile oils of rhizomes from Zingiber zerumbet. It possesses strong antitumor, antioxidant, antimicrobial, and anti-inflammatory activity. However, despite promising preclinical studies demonstrating the therapeutic utility of zerumbone, its clinical development has been limited due to its low aqueous solubility, poor absorption, or associated low bioavailability. Multiple reviews demonstrating the pharmacological effects of zerumbone for various diseases have been published. However, to our knowledge, no review demonstrates the various formulation strategies developed to overcome the biopharmaceutical challenges of zerumbone. The purpose of this review is to provide a comprehensive perspective on zerumbone as a molecule for formulation development. A section related to pharmacokinetics, toxicity, and patents of zerumbone is included. This review provides the importance of developing novel formulations of zerumbone to overcome its biopharmaceutical challenges thereby advance its potential in the treatment of various diseases. View Full-Text
Keywords: zerumbone; natural products; formulation development; drug delivery systems; pharmacological effects of zerumbone; and molecular targets of zerumbone zerumbone; natural products; formulation development; drug delivery systems; pharmacological effects of zerumbone; and molecular targets of zerumbone
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MDPI and ACS Style

Kesharwani, S.S.; Bhat, G.J. Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone. Medicina 2020, 56, 557. https://doi.org/10.3390/medicina56110557

AMA Style

Kesharwani SS, Bhat GJ. Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone. Medicina. 2020; 56(11):557. https://doi.org/10.3390/medicina56110557

Chicago/Turabian Style

Kesharwani, Siddharth S., and G. J. Bhat. 2020. "Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone" Medicina 56, no. 11: 557. https://doi.org/10.3390/medicina56110557

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