Next Article in Journal
Evaluation of Light-Emitting Diodes’ Effects on the Expression Level of P53 and EGFR in the Gingival Tissues of Albino Rats
Previous Article in Journal
Naturopathy as a Model of Prevention-Oriented, Patient-Centered Primary Care: A Disruptive Innovation in Health Care
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Medicina
Volume 55
Issue 9
10.3390/medicina55090604
medicina-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: A New Player for Cancer Immunotherapy?

by
Sofia Oliveira
1,
José Costa
1,
Isabel Faria
1,
Susana G. Guerreiro
2,3,4 and
Rúben Fernandes
1,2,*
1
School of Health, Porto Polytechnic (ESS, P. Porto), 4200 Porto, Portugal
2
Institute for Research and Innovation in Health (i3S), Porto University, 4200 Porto, Portugal
3
Faculty of Medicine, University of Porto (FMUP), 4200 Porto, Portugal
4
Faculty of Nutrition and Food Science, University of Porto (FCNAUP), 4200 Porto, Portugal
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(9), 604; https://doi.org/10.3390/medicina55090604
Submission received: 27 June 2019 / Revised: 6 September 2019 / Accepted: 9 September 2019 / Published: 18 September 2019
Browse Figures
Versions Notes

Abstract

Background and objectives: The incidence of cutaneous melanoma has been increasing. Melanoma is an aggressive form of skin cancer irresponsive to radiation and chemotherapy, rendering this cancer a disease with poor prognosis: In order to surpass some of the limitations addressed to melanoma treatment, alternatives like vitamins have been investigated. In the present study, we address this relationship and investigate the possible role of vitamin A. Materials and Methods: We perform a co-culture assay using a macrophage cell model and RAW 264.7 from mouse, and also a murine melanoma cell line B16-F10. Macrophages were stimulated with both Escherichia coli lipopolysaccharides (LPS) as control, and also with LPS plus vitamin A. Results: Using B16-F10 and RAW 264.7 cell lines, we were able to demonstrate that low concentrations of vitamin A increase cytotoxic activity of macrophages, whereas higher concentrations have the opposite effect. Conclusion: These findings can constitute a new point of view related to immunostimulation by nutrients, which may be considered one major preventive strategy by enhancing the natural defense system of the body.
Keywords: melanoma; oxidative stress; vitamin A; redox modulation; immune response melanoma; oxidative stress; vitamin A; redox modulation; immune response

Share and Cite

MDPI and ACS Style

Oliveira, S.; Costa, J.; Faria, I.; Guerreiro, S.G.; Fernandes, R. Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: A New Player for Cancer Immunotherapy? Medicina 2019, 55, 604. https://doi.org/10.3390/medicina55090604

AMA Style

Oliveira S, Costa J, Faria I, Guerreiro SG, Fernandes R. Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: A New Player for Cancer Immunotherapy? Medicina. 2019; 55(9):604. https://doi.org/10.3390/medicina55090604

Chicago/Turabian Style

Oliveira, Sofia, José Costa, Isabel Faria, Susana G. Guerreiro, and Rúben Fernandes. 2019. "Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: A New Player for Cancer Immunotherapy?" Medicina 55, no. 9: 604. https://doi.org/10.3390/medicina55090604

APA Style

Oliveira, S., Costa, J., Faria, I., Guerreiro, S. G., & Fernandes, R. (2019). Vitamin A Enhances Macrophages Activity Against B16-F10 Malignant Melanocytes: A New Player for Cancer Immunotherapy? Medicina, 55(9), 604. https://doi.org/10.3390/medicina55090604

Article Metrics

Back to TopTop