Next Article in Journal
Sexual Health in Menopause
Next Article in Special Issue
Cognitive Function and Atrial Fibrillation: From the Strength of Relationship to the Dark Side of Prevention. Is There a Contribution from Sinus Rhythm Restoration and Maintenance?
Previous Article in Journal
Effect of Primary and Secondary Beads of Carbon Enterosorbent on Haematological Parameters and Oxidative Stress Development Caused by Melphalan in Rats
Previous Article in Special Issue
Diagnosis and Management of Left Atrium Appendage Thrombosis in Atrial Fibrillation Patients Undergoing Cardioversion
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Medicina
Volume 55
Issue 9
10.3390/medicina55090558
medicina-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Polymorphism of Interleukin 1B May Modulate the Risk of Ischemic Stroke in Polish Patients

by
Iwona Gorący
1,*,
Mariusz Kaczmarczyk
1,
Andrzej Ciechanowicz
1,
Klaudyna Lewandowska
1,
Paweł Jakubiszyn
1,
Oksana Bodnar
2,
Bartosz Kopijek
3,
Andrzej Brodkiewicz
3 and
Lech Cyryłowski
4
1
Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-111 Szczecin, Poland
2
Department of General and Dental Radiology, Pomeranian Medical University, 70-111 Szczecin, Poland
3
Department of Pediatrics, Child Nephrology, Dialysotherapy and Management of Acute Poisoning, Pomeranian Medical University, 71-899 Szczecin, Poland
4
Department of Intervention Radiology, Pomeranian Medical University, 70-111 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(9), 558; https://doi.org/10.3390/medicina55090558
Submission received: 22 July 2019 / Revised: 26 August 2019 / Accepted: 28 August 2019 / Published: 2 September 2019
(This article belongs to the Special Issue Stroke, Dementia and Atrial Fibrillation)
Browse Figures
Versions Notes

Abstract

Background and Objectives: Inflammation plays a crucial role in the pathophysiology of ischemic stroke (IS). Interleukin-1B and interleukin-1 receptor antagonists are key factors in inflammatory processes. Aims: The aims of our study were to evaluate the relationship between genetic variation in interleukin-1B (IL1B) rs1143627 and interleukin-1 receptor antagonist (IL1RN) variable-number-tandem-repeats (VNTR), and overall IS and subtype prevalence rates. Materials and Methods: The analysis included 147 hospitalized Polish patients with IS diagnosed using conventional criteria. The control group consisted of 119 healthy subjects. Genotypes were determined by polymerase chain reaction. Results: A significant association between rs1143627 and stroke was found. The -31C IL1B polymorphism showed an association with overall IS, OR = 2.30 (1.36–3.87) p = 0.020. An association was also detected for LVI (large vessel infarction) subtypes of stroke. After risk factor adjustment (age, diabetes mellitus, dyslipidemia), the C allele was found to be an independent risk factor for LVI, OR = 1.99 (1.05–3.79) p = 0.036. Significant association was not observed between IL1RN alleles and IS. Conclusions: Our results suggest that the C allele of IL1B rs1143627 may be associated with susceptibility to overall IS and LVI subtypes of stroke in the Polish population.
Keywords: IL1B; IL1RN; polymorphism; stroke; inflammation IL1B; IL1RN; polymorphism; stroke; inflammation

Share and Cite

MDPI and ACS Style

Gorący, I.; Kaczmarczyk, M.; Ciechanowicz, A.; Lewandowska, K.; Jakubiszyn, P.; Bodnar, O.; Kopijek, B.; Brodkiewicz, A.; Cyryłowski, L. Polymorphism of Interleukin 1B May Modulate the Risk of Ischemic Stroke in Polish Patients. Medicina 2019, 55, 558. https://doi.org/10.3390/medicina55090558

AMA Style

Gorący I, Kaczmarczyk M, Ciechanowicz A, Lewandowska K, Jakubiszyn P, Bodnar O, Kopijek B, Brodkiewicz A, Cyryłowski L. Polymorphism of Interleukin 1B May Modulate the Risk of Ischemic Stroke in Polish Patients. Medicina. 2019; 55(9):558. https://doi.org/10.3390/medicina55090558

Chicago/Turabian Style

Gorący, Iwona, Mariusz Kaczmarczyk, Andrzej Ciechanowicz, Klaudyna Lewandowska, Paweł Jakubiszyn, Oksana Bodnar, Bartosz Kopijek, Andrzej Brodkiewicz, and Lech Cyryłowski. 2019. "Polymorphism of Interleukin 1B May Modulate the Risk of Ischemic Stroke in Polish Patients" Medicina 55, no. 9: 558. https://doi.org/10.3390/medicina55090558

APA Style

Gorący, I., Kaczmarczyk, M., Ciechanowicz, A., Lewandowska, K., Jakubiszyn, P., Bodnar, O., Kopijek, B., Brodkiewicz, A., & Cyryłowski, L. (2019). Polymorphism of Interleukin 1B May Modulate the Risk of Ischemic Stroke in Polish Patients. Medicina, 55(9), 558. https://doi.org/10.3390/medicina55090558

Article Metrics

Back to TopTop