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The Fungal Defensin Family Enlarged

Group of Animal Innate Immunity, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China
Author to whom correspondence should be addressed.
Pharmaceuticals 2014, 7(8), 866-880;
Received: 5 June 2014 / Revised: 5 August 2014 / Accepted: 8 August 2014 / Published: 18 August 2014
PDF [4030 KB, uploaded 19 August 2014]


Fungi are an emerging source of peptide antibiotics. With the availability of a large number of model fungal genome sequences, we can expect that more and more fungal defensin-like peptides (fDLPs) will be discovered by sequence similarity search. Here, we report a total of 69 new fDLPs encoded by 63 genes, in which a group of fDLPs derived from dermatophytes are defined as a new family (fDEF8) according to sequence and phylogenetic analyses. In the oleaginous fungus Mortierella alpine, fDLPs have undergone extensive gene expansion. Our work further enlarges the fungal defensin family and will help characterize new peptide antibiotics with therapeutic potential. View Full-Text
Keywords: peptide antibiotic; gene duplication; exon-intron structure; cysteine-stabilized α-helical and β-sheet motif peptide antibiotic; gene duplication; exon-intron structure; cysteine-stabilized α-helical and β-sheet motif

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Wu, J.; Gao, B.; Zhu, S. The Fungal Defensin Family Enlarged. Pharmaceuticals 2014, 7, 866-880.

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