The Fungal Defensin Family Enlarged
AbstractFungi are an emerging source of peptide antibiotics. With the availability of a large number of model fungal genome sequences, we can expect that more and more fungal defensin-like peptides (fDLPs) will be discovered by sequence similarity search. Here, we report a total of 69 new fDLPs encoded by 63 genes, in which a group of fDLPs derived from dermatophytes are defined as a new family (fDEF8) according to sequence and phylogenetic analyses. In the oleaginous fungus Mortierella alpine, fDLPs have undergone extensive gene expansion. Our work further enlarges the fungal defensin family and will help characterize new peptide antibiotics with therapeutic potential. View Full-Text
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Wu, J.; Gao, B.; Zhu, S. The Fungal Defensin Family Enlarged. Pharmaceuticals 2014, 7, 866-880.
Wu J, Gao B, Zhu S. The Fungal Defensin Family Enlarged. Pharmaceuticals. 2014; 7(8):866-880.Chicago/Turabian Style
Wu, Jiajia; Gao, Bin; Zhu, Shunyi. 2014. "The Fungal Defensin Family Enlarged." Pharmaceuticals 7, no. 8: 866-880.