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Peptides and Peptidomimetics for Antimicrobial Drug Design

Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, Postboks 260, Roskilde 4000, Denmark
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Academic Editor: Guangshun Wang
Pharmaceuticals 2015, 8(3), 366-415; https://doi.org/10.3390/ph8030366
Received: 26 March 2015 / Revised: 27 May 2015 / Accepted: 17 June 2015 / Published: 13 July 2015
The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial peptides, the contributions of individual amino acids with respect to the peptides antibacterial properties are presented. A brief discussion of the mechanisms of action of different antimicrobials as well as the development of bacterial resistance towards antimicrobial peptides follows. Finally, current efforts on novel design strategies and peptidomimetics are introduced to illustrate the importance of antimicrobial peptide research in the development of future antibiotics. View Full-Text
Keywords: antimicrobial peptides; mechanism of action; peptidomimetics antimicrobial peptides; mechanism of action; peptidomimetics
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Mojsoska, B.; Jenssen, H. Peptides and Peptidomimetics for Antimicrobial Drug Design. Pharmaceuticals 2015, 8, 366-415.

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