The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists
by
Huayun Deng and Ye Fang *
Huayun Deng and Ye Fang *
Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, NY 14831, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2013, 6(4), 500-509; https://doi.org/10.3390/ph6040500
Received: 6 March 2013 / Revised: 20 March 2013 / Accepted: 1 April 2013 / Published: 8 April 2013
(This article belongs to the Special Issue GPCR Based Drug Discovery)
Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.
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Keywords:
GPR35; benserazide; catechol; pyrogallol
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MDPI and ACS Style
Deng, H.; Fang, Y. The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists. Pharmaceuticals 2013, 6, 500-509.
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