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Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis

Division of Cardiovascular Medicine and the Gill Heart Institute, University of Kentucky, Lexington, KY 40536, USA
Lexington VA Medical Center, Lexington, KY 40536, USA
Author to whom correspondence should be addressed.
Pharmaceuticals 2013, 6(8), 915-928;
Received: 6 May 2013 / Revised: 18 July 2013 / Accepted: 26 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue GPCR Based Drug Discovery)
Platelets contribute fundamentally to ischemic heart disease, and antiplatelet therapy has been critical to reducing acute thrombotic complications of atherosclerotic disease. Thrombin, by acting on protease activated receptors (PAR), is one of the most potent platelet activators. PAR-1 antagonists may therefore provide more comprehensive antithrombotic effects. We review the pathophysiology of atherothrombosis, platelet activation by thrombin, the role of platelet protease activated receptors (PAR), and the clinical data supporting their use. View Full-Text
Keywords: platelets; thrombin; thrombosis; protease-activated receptors platelets; thrombin; thrombosis; protease-activated receptors
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Wallace, E.L.; Smyth, S.S. Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis. Pharmaceuticals 2013, 6, 915-928.

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