Next Article in Journal
Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer
Previous Article in Journal
New Aspects of Gene-Silencing for the Treatment of Cardiovascular Diseases
Previous Article in Special Issue
The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists
Article Menu

Export Article

Open AccessReview
Pharmaceuticals 2013, 6(8), 915-928;

Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis

Division of Cardiovascular Medicine and the Gill Heart Institute, University of Kentucky, Lexington, KY 40536, USA
Lexington VA Medical Center, Lexington, KY 40536, USA
Author to whom correspondence should be addressed.
Received: 6 May 2013 / Revised: 18 July 2013 / Accepted: 26 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue GPCR Based Drug Discovery)
Full-Text   |   PDF [249 KB, uploaded 2 August 2013]   |  


Platelets contribute fundamentally to ischemic heart disease, and antiplatelet therapy has been critical to reducing acute thrombotic complications of atherosclerotic disease. Thrombin, by acting on protease activated receptors (PAR), is one of the most potent platelet activators. PAR-1 antagonists may therefore provide more comprehensive antithrombotic effects. We review the pathophysiology of atherothrombosis, platelet activation by thrombin, the role of platelet protease activated receptors (PAR), and the clinical data supporting their use. View Full-Text
Keywords: platelets; thrombin; thrombosis; protease-activated receptors platelets; thrombin; thrombosis; protease-activated receptors

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Wallace, E.L.; Smyth, S.S. Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis. Pharmaceuticals 2013, 6, 915-928.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top